107425
烟酰肼
97%
别名:
烟酸酰肼
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关于此项目
经验公式（希尔记法）:
C6H7N3O
化学文摘社编号:
分子量:
137.14
UNSPSC Code:
12352100
NACRES:
NA.22
PubChem Substance ID:
EC Number:
209-041-0
Beilstein/REAXYS Number:
119299
MDL number:
Assay:
97%
InChI key
KFUSANSHCADHNJ-UHFFFAOYSA-N
InChI
1S/C6H7N3O/c7-9-6(10)5-2-1-3-8-4-5/h1-4H,7H2,(H,9,10)
SMILES string
NNC(=O)c1cccnc1
assay
97%
Quality Level
solubility
H2O: soluble 50 mg/mL
functional group
amine, hydrazine
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General description
异烟碱酰肼是一种杂环化合物，可用于合成席夫碱。
Application
烟酰肼用于腙文库形成 。用于研究辣根过氧化物酶对异烟酸酰肼（异烟肼）的氧化作用 。
Biochem/physiol Actions
烟酰肼是过氧化物酶的抑制剂 。形成具有较强生物活性的固体金属配合物 。
Preparation Note
烟酰肼溶于水中，浓度为 50 mg/mL，形成澄清、无色溶液。
signalword
Warning
hcodes
pcodes
Hazard Classifications
Eye Irrit. 2
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
V Goral et al.
Proceedings of the National Academy of Sciences of the United States of America, 98(4), 1347-1352 (2001-02-15)
Dynamic combinatorial libraries are mixtures of compounds that exist in a dynamic equilibrium and can be driven to compositional self adaptation via selective binding of a specific assembly of certain components to a molecular target. We present here an extension
Thermo-chemical behavior of solid nicotinic hydrazide metal complexes in correlation with their stoichiometry.
Sekkina MM and El-Azm MG.
Thermochimica Acta, 77(1), 211-218 (1984)
H A Shoeb et al.
Antimicrobial agents and chemotherapy, 27(3), 399-403 (1985-03-01)
Oxidation of isonicotinic acid hydrazide (isoniazid) by horseradish peroxidase at the expense of H2O2 yielded reactive species which were able to reduce nitroblue tetrazolium and bleach p-nitrosodimethylaniline. Nicotinic acid hydrazide oxidation did not cause these effects. At slightly alkaline pH
Synthesis, spectroscopic characterization, and crystal structures of Schiff bases derived from nicotinic hydrazide
Diouf F, et al.
IOSR journal of applied chemistry, 1 serie II (2022)
B J van der Walt et al.
The International journal of biochemistry, 26(9), 1081-1093 (1994-09-01)
1. Superoxide was generated during the auto-oxidation of the antituberculous drug, isonicotinic acid hydrazide (INH), but not with its meta-isomer, nicotinic acid hydrazide (NH). During Fe(3+)-stimulated oxidation of INH and NH, aromatic hydroxylation occurred which was inhibited by the chelating
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