10907
氯乙醛 溶液
Wacker Chemie AG, ≥45.0% in H2O (density determination)
别名:
CLACH
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关于此项目
线性分子式:
ClCH2CHO
化学文摘社编号:
分子量:
78.50
UNSPSC Code:
12352100
NACRES:
NA.22
PubChem Substance ID:
EC Number:
203-472-8
Beilstein/REAXYS Number:
1071226
MDL number:
Form:
solid
InChI key
QSKPIOLLBIHNAC-UHFFFAOYSA-N
InChI
1S/C2H3ClO/c3-1-2-4/h2H,1H2
SMILES string
[H]C(=O)CCl
form
solid
manufacturer/tradename
Wacker Chemie AG
concentration
≥45.0% in H2O (density determination)
bp
80-100 °C (lit.)
functional group
aldehyde, chloro
Quality Level
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Application
Chloroacetaldehyde is a reagent used for converting adenine and its nucleoseides into fluorescent etheno derivatives which can be analysed by HPLC. It was used for derivatization in fluorometric determination of arprinocid and analogous compounds in human plasma .
Biochem/physiol Actions
Chloroacetaldehyde, a metabolite of ifosamide, influences oxidative phosphorylation in mitochondria. It causes breaking of DNA strands and strongly inhibits DNA synthesis.
Other Notes
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signalword
Danger
Hazard Classifications
Acute Tox. 1 Inhalation - Acute Tox. 2 Dermal - Acute Tox. 3 Oral - Aquatic Acute 1 - Carc. 2 - Eye Dam. 1 - Skin Corr. 1B - STOT SE 3
target_organs
Respiratory system
存储类别
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
wgk
WGK 3
flash_point_f
143.6 °F - closed cup
flash_point_c
62 °C - closed cup
ppe
Eyeshields, Gloves, type ABEK (EN14387) respirator filter
法规信息
新产品
此项目有
Preparation, titration, and storage of chloroacetaldehyde for fluorometric determination of adenine and its derivatives.
McCann WP, et al.
Analytical Chemistry, 55(8), 1454-1455 (1983)
Fluorogenic reaction between adenine derivatives and chloroacetaldehyde and its application to the determination of 9-(2-chloro-6-fluorobenzyl) adenine in human plasma.
Matuszewski BK and Bayne WF.
Analytica Chimica Acta, 227, 189-202 (1989)
Svenja K Brüggemann et al.
Cancer chemotherapy and pharmacology, 57(3), 349-356 (2005-09-01)
The ifosfamide metabolite chloroacetaldehyde had been made responsible for side effects only. We found in previous studies a strong cytotoxicity on human MX-1 tumor cells and xenografts in nude mice. Chloroacetaldehyde is supposed to act via alkylation or by inhibition
Stephanie L MacAllister et al.
Chemico-biological interactions, 202(1-3), 259-266 (2012-12-12)
Cyclophosphamide and ifosfamide are two commonly used DNA-alkylating agents in cancer chemotherapy that undergo biotransformation to several toxic and non-toxic metabolites, including acrolein and chloroacetaldehyde (CAA). Acrolein and CAA toxicities occur by several different mechanisms, including ROS formation and protein
Dhaval P Bhatt et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 889-890, 110-115 (2012-03-03)
In mono-layered primary cell cultures baseline AMP and ADP levels are found nominally in the mid to low picomolar range and are thus difficult to measure with conventional HPLC methods that often require the pooling of samples or require indirect
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