Merck
CN

109185

Sigma-Aldrich

糖精

≥98%

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别名:
2,3-二羟基-1,2-苯并异噻唑基-3-酮-1,1-二氧化物, 2-磺基苯甲酸亚胺, 邻磺酰苯酰亚胺
Empirical Formula (Hill Notation):
C7H5NO3S
CAS号:
分子量:
183.18
Beilstein:
6888
EC 号:
MDL编号:
PubChem化学物质编号:
NACRES:
NA.22

质量水平

检测方案

≥98%

mp

226-229 °C (lit.)

溶解性

H2O: soluble 1g in 290ml
acetone: soluble 1g in 12ml
alcohol: soluble 1g in 31ml
boiling water: soluble 1g in 25ml
glycerol: soluble 1g in 50ml
alcohol: very slightly soluble
chloroform: slightly soluble
diethyl ether: slightly soluble

SMILES string

O=C1NS(=O)(=O)c2ccccc12

InChI

1S/C7H5NO3S/c9-7-5-3-1-2-4-6(5)12(10,11)8-7/h1-4H,(H,8,9)

InChI key

CVHZOJJKTDOEJC-UHFFFAOYSA-N

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240931PHR1341S0040000
Saccharin ≥98%

Sigma-Aldrich

109185

糖精

Saccharin ≥99%

Sigma-Aldrich

240931

糖精

Saccharin Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR1341

糖精钠

Saccharin European Pharmacopoeia (EP) Reference Standard

S0040000

糖精

mp

226-229 °C (lit.)

mp

226-229 °C (lit.)

mp

226-229 °C (lit.)

mp

226-229 °C (lit.)

solubility

H2O: soluble 1g in 290ml, acetone: soluble 1g in 12ml, alcohol: soluble 1g in 31ml, boiling water: soluble 1g in 25ml, glycerol: soluble 1g in 50ml, alcohol: very slightly soluble, chloroform: slightly soluble, diethyl ether: slightly soluble

solubility

acetone: 1g in 12mL(lit.), alcohol: 1g in 31mL(lit.), boiling water: 1g in 25mL(lit.)

solubility

-

solubility

-

应用

高效液相色谱法采用糖精对乙酰磺胺酸钾、糖精和阿斯巴甜进行同时分离和测定 。用于大鼠的甜味偏好测试

生化/生理作用

N-甲基-N′-硝基-N-亚硝基胍后给予糖精促进大鼠肿瘤的发展
哺乳动物的甜促味剂。有人提出,果蝇具有葡萄糖特异性甘油味觉受体结合位点。

储存分类代码

11 - Combustible Solids

WGK

WGK 2

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)


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USP

USP

1607040

糖精 钠盐 二水合物

Acesulfame K for food analysis, ≥99.0%

Supelco

04054

安赛蜜

Saccharin calcium United States Pharmacopeia (USP) Reference Standard

USP

1607029

糖精 半钙盐

Acesulfame potassium European Pharmacopoeia (EP) Reference Standard

A0070000

安赛蜜

M Takahashi et al.
Gan, 75(6), 494-501 (1984-06-01)
Sodium chloride, saccharin sodium, phenobarbital sodium and aspirin were tested for tumor-promoting activity in the glandular stomach of rats after initiation with N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) coupled with administration of a high salt diet. Male outbred Wistar rats were given MNNG in
Anne Marie Vinggaard et al.
Toxicological sciences : an official journal of the Society of Toxicology, 85(2), 886-897 (2005-03-25)
Prochloraz is a commonly used fungicide that has shown multiple mechanisms of action in vitro. It antagonizes the androgen and the estrogen receptors, agonizes the Ah receptor, and inhibits aromatase activity. In vivo prochloraz acts antiandrogenically in the Hershberger assay
Simultaneous determination of artificial sweeteners in possible counterfeited wines, using high performance liquid chromatography with DAD detection.
Geana EI, et al.
Analele Universitatii Ovidius din Constanta-Seria Chimie, 23(1), 77-81 (2012)
Katharine J Tuerke et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 32(40), 13709-13717 (2012-10-05)
A taste associated with emetic drugs produces conditioned disgust reactions in rats (predominantly gaping), unlike nonemetic drugs that can still produce conditioned taste avoidance but not conditioned disgust. That difference suggests nausea is a prerequisite for learning disgust reactions to
Sharon O Jensen-Cody et al.
Cell metabolism, 32(2), 273-286 (2020-07-09)
Fibroblast growth factor 21 (FGF21) is an endocrine hormone produced by the liver that regulates nutrient and metabolic homeostasis. FGF21 production is increased in response to macronutrient imbalance and signals to the brain to suppress sugar intake and sweet-taste preference.

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