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Merck
CN

11373

HATU

≥98.0% (CHN), for peptide synthesis

别名:

1-[Bis(dimethylamino)methylene]-1H-1,2,3-triazolo[4,5-b]pyridinium 3-oxid hexafluorophosphate, N-[(Dimethylamino)-1H-1,2,3-triazolo-[4,5-b]pyridin-1-ylmethylene]-N-methylmethanaminium hexafluorophosphate N-oxide

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关于此项目

经验公式（希尔记法）:
C10H15F6N6OP
化学文摘社编号:
148893-10-1
分子量:
380.23
UNSPSC Code:
12352302
PubChem Substance ID:
57646915
NACRES:
NA.22
MDL number:
MFCD27957364

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产品名称

HATU, ≥98.0% (CHN)

SMILES string

F[P-](F)(F)(F)(F)F.CN(C)[C+](N(C)C)n1n[n+]([O-])c2ncccc12

InChI

1S/C10H15N6O.F6P/c1-13(2)10(14(3)4)15-8-6-5-7-11-9(8)16(17)12-15;1-7(2,3,4,5)6/h5-7H,1-4H3;/q+1;-1

InChI key

FKBFHOSFPRWJNV-UHFFFAOYSA-N

assay

≥98.0% (CHN)

form

solid

reaction suitability

reaction type: Coupling Reactions

mp

183-185 °C (lit.)
183-188 °C (dec.)

application(s)

peptide synthesis

functional group

amine

storage temp.

2-8°C

Quality Level

100

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Application

Reagent for:
Synthesis of Aurora A kinase inhibitors
HPLC assay to determine D- and L- acid enantiomers in human plasma
Amide bond formation reactions

Catalyst for:
Selective acylation
Selecocyclization-oxidation deselenation sequence

Other Notes

Recent studies show that crystal as well as solution structure of this coupling agent is a guanidinium N-oxide and not an uronium compound; Advantageous coupling reagent for solid-phase peptide synthesis.

pictograms

Health hazard
GHS08

signalword

Danger

hcodes

H317,H334

Hazard Classifications

Resp. Sens. 1 - Skin Sens. 1A

supp_hazards

EUH044

存储类别

4.1A - Other explosive hazardous materials

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
WXBD3228V
SDBB3706
STBL4782
STBL1490
STBL0066

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The uronium/guanidinium Peptide coupling reagents: finally the true uronium salts.
Louis A Carpino et al.
Angewandte Chemie (International ed. in English), 41(3), 441-445 (2002-12-20)
Qingxin Chen et al.
Journal of virology, 94(19) (2020-07-17)
Adeno-associated virus (AAV) has proven to be a promising candidate for gene therapy due to its nonpathogenic nature, ease of production, and broad tissue tropism. However, its transduction capabilities are not optimal due to the interaction with various host factors
L. Carpino et al.
Journal of the Chemical Society. Chemical Communications, 201-201 (1994)
Mazen Jamous et al.
Nuclear medicine and biology, 41(6), 464-470 (2014-05-02)
The gastrin-releasing peptide receptor (GRPR) was shown to be expressed with high density on several types of cancers. Radiolabeled peptides for imaging and targeted radionuclide therapy have been developed. In this study, we evaluated the potential of statine-based bombesin antagonists
Anna K Lee et al.
Molecular cell, 79(4), 645-659 (2020-07-22)
Stress granules (SGs) are membrane-less ribonucleoprotein condensates that form in response to various stress stimuli via phase separation. SGs act as a protective mechanism to cope with acute stress, but persistent SGs have cytotoxic effects that are associated with several
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