115053
4-硝基苯乙基溴
98%
别名:
1-(2-溴乙基)-4-硝基苯, 2-(4-硝基苯基)乙基溴
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关于此项目
线性分子式:
O2NC6H4CH2CH2Br
化学文摘社编号:
分子量:
230.06
Beilstein:
1909321
EC 号:
MDL编号:
UNSPSC代码:
12352100
PubChem化学物质编号:
方案
98%
表单
solid
mp
67-69 °C (lit.)
官能团
bromo
nitro
SMILES字符串
[O-][N+](=O)c1ccc(CCBr)cc1
InChI
1S/C8H8BrNO2/c9-6-5-7-1-3-8(4-2-7)10(11)12/h1-4H,5-6H2
InChI key
NTURQZFFJDCTMZ-UHFFFAOYSA-N
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一般描述
4-nitrophenethyl bromide is an electrophile which accepts a lone pair of electrons from one of the nitrogen atoms in the polyazamacrocycle.
应用
4-nitrophenethyl bromide is used a s a GST T1-1 substrate for identifying many kinetic parameters (Km, Kcat) for hGST T1-1 variants.
生化/生理作用
4-Nitrophenethyl bromide is used as a marker in for the θ-class of glutathione S-transferases (GSTs). It activates the human θ-class glutathione transferase T1-1 enzyme.
警示用语：
Warning
危险分类
Eye Irrit. 2 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3
靶器官
Respiratory system
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
法规信息
新产品
此项目有
Abeer Shokeer et al.
The Biochemical journal, 388(Pt 1), 387-392 (2005-02-03)
GST (glutathione transferase) T1-1 plays an important role in the biotransformation of halogenated alkanes, which are used in large quantities as solvents and occur as environmental pollutants. Many reactions that are catalysed by GST T1-1 qualify as detoxification processes, but
M F Lopez et al.
Biochimica et biophysica acta, 1205(1), 29-38 (1994-03-16)
A novel glutathione S-transferase (GST) was purified from broccoli (Brassica oleracea var. italica). Partial amino-acid sequencing indicated that the protein shared significant homology with several different plant GSTs from maize, silene, Dianthus, Nicotiana and Triticum, but little homology to yeast
Birute Surinenaite et al.
Biotechnology and applied biochemistry, 36(Pt 1), 47-55 (2002-08-01)
The lipase from Pseudomonas mendocina 3121-1 was found to be homogeneous with a molecular mass of 30 kDa by SDS/PAGE. It is composed of two identical subunits. A molecular mass of 62 kDa was determined by gel chromatography on a
M D Neranjan Tharuka et al.
Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology, 214, 1-11 (2017-09-09)
Glutathione S-transferases (GSTs, EC 2.5.1.18) are important Phase II detoxifying enzymes that catalyze hydrophobic, electrophilic xenobiotic substance with the conjugation of reduced glutathione (GSH). In this study, GSTμ and GSTρ paralogs of GST in the big belly seahorse (Hippocampus abdominalis;
J Ozaki et al.
European journal of pharmacology, 370(3), 307-312 (1999-05-20)
We compared the enzymatic inactivation of major circulating forms of atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP). Both ANP and BNP induced a significant increase in cyclic GMP (cGMP) formation in cultured epithelial cell line derived from porcine
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