115312
N-ω-甲基色胺
99%
别名:
2-(吲哚-3-基)-N-甲基乙胺, 3-(2-[甲氨基]乙基)吲哚, 3-(2-甲基氨基乙基)吲哚, N-单甲基色胺, N10-甲基色胺, 甲基色胺
质量水平
方案
99%
表单
solid
mp
87-89 °C (lit.)
官能团
amine
SMILES字符串
CNCCc1c[nH]c2ccccc12
InChI
1S/C11H14N2/c1-12-7-6-9-8-13-11-5-3-2-4-10(9)11/h2-5,8,12-13H,6-7H2,1H3
InChI key
NCIKQJBVUNUXLW-UHFFFAOYSA-N
应用
N-ω-甲基色胺已用于制备N-乙酰基-α−甲基色胺。
N-ω-甲基色胺已用于通过钩藤(U. tomentosa)蛋白提取物生物合成dolichantoside。
作为反应物用于制备：
- Manzamine类似物用于控制神经炎症和脑部感染
- 血清素4受体(5-HT4)受体激动剂
- Glypetelotine，一种含硫的吲哚生物碱
- 周期蛋白依赖性激酶(CDK4)的选择性抑制剂
- 人速激肽NK-2受体拮抗剂
- 酪氨酸特异性蛋白激酶pp60c-src SH2结构域的抑制剂
包装
无底玻璃瓶。内含物装在锥底内插管中。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
Luigi Servillo et al.
Journal of agricultural and food chemistry, 60(37), 9512-9518 (2012-09-11)
The occurrence of N-methylated tryptamine derivatives in bergamot plant (Citrus bergamia Risso et Poit) is reported for the first time. Interestingly, the most abundant of these substances is N,N,N-trimethyltryptamine, which has not been previously identified in any citrus plant. The
R W Walker et al.
Journal of chromatography, 289, 223-229 (1984-04-27)
A capillary column gas-liquid chromatography selected ion monitoring-based method was developed for the measurement of [13C,15N]N-methyltryptamine ( NMT ) in human urine. The method was employed to establish the extent of conversion of [13C,15N]tryptamine to the correspondingly labeled NMT in
T J Williams et al.
European journal of pharmacology, 245(3), 197-201 (1993-05-15)
The binding of [3H]5-hydroxytryptamine (5-HT) to rat enteric membranes was inhibited by the inclusion of 5-HT 2-methyl-5-HT, 5-hydroxytryptophan, N,N,N-triethyltryptamine and 2-Br-N,N-diethyltryptamine in the incubation buffer. In contrast, tryptamine, 5-methoxytryptamine and 2-methyl-N,N-diethyltryptamine enhanced binding. Ascorbate and dithiothreitol facilitated and reduced binding
Strictosidine-related enzymes involved in the alkaloid biosynthesis of Uncaria tomentosa root cultures grown under oxidative stress.
Vera-Reyes I, Huerta-Heredia AA, Ponce-Noyola T, et al.
Biotechnology Progress, doi:10-doi:10 (2013)
K J Willis et al.
Biophysical journal, 57(2), 183-189 (1990-02-01)
Direct and indirect methods are described to combine steady-state and picosecond time-resolved fluorescence decay data to generate decay-associated excitation spectra. The heterogeneous fluorescence from a fluorophore mixture that models protein fluorescence was resolved into individual component excitation spectra. The two
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