115673
2-溴-3′-甲氧基苯乙酮
98%
别名:
3′-甲氧基苯乙酰溴
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关于此项目
线性分子式:
CH3OC6H4COCH2Br
化学文摘社编号:
分子量:
229.07
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352100
EC Number:
225-666-1
MDL number:
Assay:
98%
InChI key
IOOHBIFQNQQUFI-UHFFFAOYSA-N
InChI
1S/C9H9BrO2/c1-12-8-4-2-3-7(5-8)9(11)6-10/h2-5H,6H2,1H3
SMILES string
COc1cccc(c1)C(=O)CBr
assay
98%
mp
60-62 °C (lit.)
functional group
bromo, ketone
storage temp.
2-8°C
Quality Level
Application
2-溴-3′-甲氧基苯乙酮是一种烷化剂，用于稳定人血浆中的氯吡格雷活性代谢产物 (AM) 。也用于血液中活性代谢物的衍生化，以确保其在样本处理和储存期间的稳定性 。
signalword
Danger
hcodes
Hazard Classifications
Eye Dam. 1 - Skin Corr. 1B - STOT SE 3
target_organs
Respiratory system
存储类别
8A - Combustible corrosive hazardous materials
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
Nagy A Farid et al.
Rapid communications in mass spectrometry : RCM, 21(2), 169-179 (2006-12-13)
Two fast and sensitive liquid chromatography/tandem mass spectrometry (LC/MS/MS)-based bioanalytical assays were developed and validated to quantify the active and three inactive metabolites of prasugrel. Prasugrel is a novel thienopyridine prodrug that is metabolized to the pharmacologically active metabolite in
Makoto Takahashi et al.
Journal of pharmaceutical and biomedical analysis, 48(4), 1219-1224 (2008-10-03)
A quantitative method for the determination of clopidogrel active metabolite (AM) in human plasma was developed and validated using liquid chromatography-tandem mass spectrometry (LC-MS/MS). Clopidogrel AM contains a thiol group, thus requiring stabilization in biological samples. The alkylating reagent 2-bromo-3'-methoxyacetophenone
Jinfang Jiang et al.
Frontiers in pharmacology, 8, 846-846 (2017-12-07)
Vicagrel, a structural analog of clopidogrel, is now being developed as a thienopyridine antiplatelet agent in a phase II clinical trial in China. Some studies have shown that vicagrel undergoes complete first-pass metabolism in human intestine, generating the hydrolytic metabolite
Jin-Zi Ji et al.
Biochemical pharmacology, 183, 114313-114313 (2020-11-03)
Variability in P-glycoprotein (P-gp) efflux transporting activity was supposed to be involved in altered intestinal absorption and bioavailability of clopidogrel in patients; however, reliable evidence is still lacking. In this study, we sought to determine whether P-gp could play an
Hongwei Yao et al.
Biochemical pharmacology, 180, 114142-114142 (2020-07-13)
Patients with diabetic mellitus tend to have a poor response to clopidogrel (Clop) due to reduced generation of active metabolite (Clop-AM). However, the underlying mechanism is not elucidated. A type 2 diabetic mellitus (T2DM) rat model was established by combining
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