116238
5,7-二甲氧基香豆素
98%
别名:
利美汀, 柠檬油素
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关于此项目
经验公式（希尔记法）:
C11H10O4
化学文摘社编号:
分子量:
206.19
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352100
EC Number:
207-646-4
MDL number:
Assay:
98%
Form:
solid
InChI key
NXJCRELRQHZBQA-UHFFFAOYSA-N
InChI
1S/C11H10O4/c1-13-7-5-9(14-2)8-3-4-11(12)15-10(8)6-7/h3-6H,1-2H3
SMILES string
COc1cc(OC)c2C=CC(=O)Oc2c1
assay
98%
form
solid
mp
146-149 °C (lit.)
functional group
ester
Quality Level
General description
从茴香 H. Mann 的叶子和果实中分离和鉴定出 5,7-二甲氧基香豆素，该植物的果实用于构建莫霍克花环。它在细菌中诱导移码诱变。它还会在中国仓鼠细胞中引起致命的光敏化和姐妹染色单体交换的形成。
Biochem/physiol Actions
5,7-二甲氧基香豆素诱导小鼠（B16） 和人类（A375） 的分化和黑色素生成过程。
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Jinglan Han et al.
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 34(17), 2200-2202 (2009-12-01)
To study the chemical constituents from Lobelia chinensis. The constituents were extracted with 95% EtOH, partitioned with different solvents, and isolated and purified by silica gel column chromatography and crystallization, their structures were elucidated by physico-chemical properties and spectroscopic data.
E Gorgus et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 48(1), 93-98 (2009-09-23)
Phototoxic and photo-genotoxic furocoumarins occur, e.g., in citrus species, parsnip, parsley, celery, and figs. They exhibit phototoxic and photo-genotoxic properties in combination with UV radiation, while less is known about the phototoxicity of the coumarin derivative limettin mainly found in
Earl Grey tea intoxication.
Josef Finsterer
Lancet (London, England), 359(9316), 1484-1484 (2002-05-04)
Daniela Alesiani et al.
International journal of oncology, 32(2), 425-434 (2008-01-19)
In the present study we investigated the antiproliferative activity of 5,7-dimethoxycoumarin on the murine B16 and human A375 melanoma cell lines. The inhibitory concentration 50 (IC50) was estimated for each cell line by preliminary assay of tetrazolium salt reduction (MTT).
Isolation and characterization of the photoadducts of 5,7-dimethoxycoumarin and adenosine.
T H Cho et al.
Photochemistry and photobiology, 46(2), 305-309 (1987-08-01)
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