11970
苯丙烯酰苯
≥98.0% (GC)
别名:
亚苄基乙酰苯, 查耳酮
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关于此项目
线性分子式:
C6H5CH=CHCOC6H5
化学文摘社编号:
分子量:
208.26
UNSPSC Code:
12352100
NACRES:
NA.22
PubChem Substance ID:
EC Number:
202-330-2
Beilstein/REAXYS Number:
1210466
MDL number:
Assay:
≥98.0% (GC)
assay
≥98.0% (GC)
solubility
dioxane: soluble 1 g/10 mL, clear, colorless
functional group
ketone, phenyl
SMILES string
O=C(\C=C\c1ccccc1)c2ccccc2
InChI
1S/C15H12O/c16-15(14-9-5-2-6-10-14)12-11-13-7-3-1-4-8-13/h1-12H/b12-11+
InChI key
DQFBYFPFKXHELB-VAWYXSNFSA-N
Gene Information
rat ... Ar(24208)
Application
1,3-二苯基-2-丙烯酮被用于制备具有药理学意义的杂环系统，如吡唑啉和嘧啶 。
Biochem/physiol Actions
1，3-二苯基-2-丙烯酮（查尔酮）通过诱导细胞凋亡，阻断细胞周期 G2/M 期进程，从而抑制人乳腺癌细胞株 MCF-7 和 MDA-MB-231 的增殖 。它是恶性疟原虫周期素依赖性蛋白激酶的抑制剂。
存储类别
11 - Combustible Solids
wgk
WGK 3
ppe
dust mask type N95 (US), Eyeshields, Gloves
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Selective inhibition of Pfmrk, a Plasmodium falciparum CDK, by antimalarial 1,3-diaryl-2-propenones.
Jeanne A Geyer et al.
Bioorganic & medicinal chemistry letters, 19(7), 1982-1985 (2009-03-03)
The cyclin dependent protein kinases, Pfmrk and PfPK5, most likely play an essential role in cell cycle control and differentiation in Plasmodium falciparum and are thus an attractive target for antimalarial drug development. Various 1,3-diaryl-2-propenones (chalcone derivatives) which selectivity inhibit
André Sousa et al.
The journal of physical chemistry. B, 117(6), 1901-1910 (2013-01-17)
Two oaklins guaiacylcatechinpyrylium (GCP) and syringylcatechinpyrylium (SCP) and a model compound deoxypeonidin (DOP) were synthesized, and the rate and equilibrium constants of the respective pH dependent network of chemical reactions were calculated. In contrast to anthocyanins, the three compounds possess
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| D91535-250MG | 04061833590300 |
| 11970-100G | 04061838712295 |