11970
苯丙烯酰苯
≥98.0% (GC)
别名:
亚苄基乙酰苯, 查耳酮
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关于此项目
线性分子式:
C6H5CH=CHCOC6H5
化学文摘社编号:
分子量:
208.26
UNSPSC Code:
12352100
NACRES:
NA.22
PubChem Substance ID:
EC Number:
202-330-2
Beilstein/REAXYS Number:
1210466
MDL number:
Assay:
≥98.0% (GC)
InChI key
DQFBYFPFKXHELB-VAWYXSNFSA-N
InChI
1S/C15H12O/c16-15(14-9-5-2-6-10-14)12-11-13-7-3-1-4-8-13/h1-12H/b12-11+
SMILES string
O=C(\C=C\c1ccccc1)c2ccccc2
assay
≥98.0% (GC)
solubility
dioxane: soluble 1 g/10 mL, clear, colorless
functional group
ketone, phenyl
Gene Information
rat ... Ar(24208)
Application
1,3-二苯基-2-丙烯酮被用于制备具有药理学意义的杂环系统，如吡唑啉和嘧啶 。
Biochem/physiol Actions
1，3-二苯基-2-丙烯酮（查尔酮）通过诱导细胞凋亡，阻断细胞周期 G2/M 期进程，从而抑制人乳腺癌细胞株 MCF-7 和 MDA-MB-231 的增殖 。它是恶性疟原虫周期素依赖性蛋白激酶的抑制剂。
存储类别
11 - Combustible Solids
wgk
WGK 3
ppe
dust mask type N95 (US), Eyeshields, Gloves
Conventional and Microwave assisted Synthesis of 1, 3- Diphenyl -2- Propenone derivatives and Cytotoxic, Anti bacterial activites.
Ahmad MR and Bano N.
International Journal of ChemTech Research, 3(3), 1470-1478 (2011)
Yau-Hung Chen et al.
Molecules (Basel, Switzerland), 18(2), 2052-2060 (2013-02-07)
The aim of this study was to investigate novel chalcones with potent anti-inflammatory activities in vivo. Chalcone and two chalcone analogues (compound 5 and 9) were evaluated using a caudal fin-wounded transgenic zebrafish line "Tg(mpx:gfp)" to visualize the effect of
Lijuan Song et al.
Fitoterapia, 84, 107-114 (2012-11-20)
Hydroxysafflor yellow A (HSYA) is an active ingredient obtained from the flower of Carthamus tinctorius L. The present study investigated the effects of HSYA on lipopolysaccharide (LPS)-induced inflammatory signal transduction in human alveolar epithelial A549 cells. A549 cells stimulated with
Zijing Li et al.
Journal of medicinal chemistry, 56(2), 471-482 (2012-12-18)
Rhenium and technetium-99m cyclopentadienyl tricarbonyl complexes mimicking the chalcone structure were prepared. These complexes were proved to have affinity to β-amyloid (Aβ) in fluorescent staining on brain sections of Alzheimer's Disease (AD) patient and binding assay using Aβ(1-42) aggregates, with
Jie Li et al.
Neuroscience letters, 535, 51-56 (2013-01-22)
Inflammation is a pivotal pathological progress in the development of ischemic stroke. Modulating inflammatory cytokines released by microglia is thought to be a potential strategy for the treatment of ischemic stroke. Hydroxy-safflor yellow A (HSYA), a chemical component of the
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