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123129

2-氨基噻唑

Name: 2-氨基噻唑
Brand: ALDRICH

97%

别名:

2-噻唑胺

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关于此项目

经验公式（希尔记法）:

C₃H₄N₂S

化学文摘社编号:

96-50-4

分子量:

100.14

UNSPSC Code:

12352100

NACRES:

NA.22

PubChem Substance ID:

24847523

EC Number:

202-511-6

Beilstein/REAXYS Number:

105738

MDL number:

MFCD00005325

Assay:

97%

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属性

Quality Level

100

assay

97%

mp

91-93 °C (lit.)

solubility

1 M HCl: soluble 50 mg/mL, clear (dark yellow-brown)

SMILES string

Nc1nccs1

InChI

1S/C3H4N2S/c4-3-5-1-2-6-3/h1-2H,(H2,4,5)

InChI key

RAIPHJJURHTUIC-UHFFFAOYSA-N

说明

Application

2-氨基噻唑用于合成 2-氨基噻唑修饰硅胶。在超声辐射介导下与 2-氯苯甲酸进行 Ulmann 偶联。

Biochem/physiol Actions

2-氨基噻唑是有效的细胞周期蛋白依赖性激酶 5 抑制剂，是治疗阿尔茨海默病和其他神经退行性疾病的治疗药物。

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pictograms

GHS07

signalword

Warning

hcodes

H302

pcodes

P264 - P270 - P301 + P312 - P501

Hazard Classifications

Acute Tox. 4 Oral

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Discovery and SAR of 2-aminothiazole inhibitors of cyclin-dependent kinase 5/p25 as a potential treatment for Alzheimer's disease.

Christopher J Helal et al.

Bioorganic & medicinal chemistry letters, 14(22), 5521-5525 (2004-10-16)

High-throughput screening with cyclin-dependent kinase 5 (cdk5)/p25 led to the discovery of N-(5-isopropyl-thiazol-2-yl)isobutyramide (1). This compound is an equipotent inhibitor of cdk5 and cyclin-dependent kinase 2 (cdk2)/cyclin E (IC(50)=ca. 320nM). Parallel and directed synthesis techniques were utilized to explore the

Determination of Cu, Ni, and Zn in fuel ethanol by FAAS after enrichment in column packed with 2-aminothiazole-modified silica gel.

P S Roldan et al.

Analytical and bioanalytical chemistry, 375(4), 574-577 (2003-03-01)

This work describes the synthesis and characterization of 2-aminothiazole-modified silica gel (SiAT), as well as its application for preconcentration (in batch and column technique) of Cu(II), Ni(II) and Zn(II) in ethanol medium. The adsorption capacities of SiAT determined for each

Synthesis and biological activity of 2-aminothiazoles as novel inhibitors of PGE2 production in cells.

Breland Smith et al.

Bioorganic & medicinal chemistry letters, 22(10), 3567-3570 (2012-04-21)

This Letter presents the synthesis and biological evaluation of a collection of 2-aminothiazoles as a novel class of compounds with the capability to reduce the production of PGE(2) in HCA-7 human adenocarcinoma cells. A total of 36 analogs were synthesized

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全球贸易项目编号

货号	GTIN
123129-5G	04061838722102
123129-100G	04061838722089
123129-500G	04061838722096