126136
甲基丙二酸二乙酯
99%
别名:
Methylmalonic acid diethyl ester
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关于此项目
线性分子式:
CH3CH(COOC2H5)2
化学文摘社编号:
分子量:
174.19
UNSPSC Code:
12352100
NACRES:
NA.22
PubChem Substance ID:
EC Number:
210-175-7
Beilstein/REAXYS Number:
637028
MDL number:
Assay:
99%
Quality Level
assay
99%
refractive index
n20/D 1.413 (lit.)
bp
198-199 °C (lit.), 78-80 °C/10 mmHg
density
1.022 g/mL at 20 °C (lit.)
SMILES string
CCOC(=O)C(C)C(=O)OCC
InChI
1S/C8H14O4/c1-4-11-7(9)6(3)8(10)12-5-2/h6H,4-5H2,1-3H3
InChI key
UPQZOUHVTJNGFK-UHFFFAOYSA-N
General description
在异常 Michael 条件下，甲基丙二酸二乙酯与2-环己烯酮反应，形成2-(3-氧代环己基)-2-环己烯酮。它在聚合转移催化过程中引起聚(氯甲基苯乙烯)的烷基化。
Application
甲基丙二酸二乙酯被用于研究直接补充甲基丙二酸二酯的培养基对红色糖多孢菌（Saccharopolyspora erythraea ）mutB菌株的红霉素发酵的影响。
存储类别
10 - Combustible liquids
wgk
WGK 3
flash_point_f
179.6 °F - closed cup
flash_point_c
82 °C - closed cup
ppe
Eyeshields, Gloves, type ABEK (EN14387) respirator filter
Alkylation reaction of poly (chloromethylstyrene) with malononitrile and diethyl methylmalonate using phase transfer catalysts.
Nishikubo T, et al.
Makromol. Chem., 2(6-7), 387-392 (1981)
J Mark Weber et al.
Applied microbiology and biotechnology, 93(4), 1575-1583 (2011-11-04)
The Saccharopolyspora erythraea mutB knockout strain, FL2281, having a block in the methylmalonyl-CoA mutase reaction, was found to carry a diethyl methylmalonate-responsive (Dmr) phenotype in an oil-based fermentation medium. The Dmr phenotype confers the ability to increase erythromycin A (erythromycin)
Abnormal Michael reaction. Reaction between 2-cyclohexenone and diethyl methylmalonate.
Risinger GE and Haag WG.
The Journal of Organic Chemistry, 38(20), 3546-3647 (1973)
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| 1623580-1ML | 04061842433940 |
| 525286-4L | 04061838128300 |
| 525286-250ML | 04061838128294 |
| 525286-20L | 04061838120168 |
| 126136-100G | 04061838723864 |
| 126136-500G | 04061837368264 |