129550
4-(2-酮酸-1-苯并咪唑)哌啶
98%
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关于此项目
经验公式（希尔记法）:
C12H15N3O
化学文摘社编号:
分子量:
217.27
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352100
EC Number:
243-950-3
MDL number:
Assay:
98%
Form:
solid
InChI key
BYNBAMHAURJNTR-UHFFFAOYSA-N
InChI
1S/C12H15N3O/c16-12-14-10-3-1-2-4-11(10)15(12)9-5-7-13-8-6-9/h1-4,9,13H,5-8H2,(H,14,16)
SMILES string
O=C1Nc2ccccc2N1C3CCNCC3
assay
98%
form
solid
mp
183-185 °C (lit.)
Quality Level
Application
4-(2-Keto-1-benzimidazolinyl)piperidine was used to study the structure–activity relationships with several potent and selective analogues.
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
Mike Frohn et al.
Bioorganic & medicinal chemistry letters, 17(23), 6633-6637 (2007-10-09)
We report the development of the novel N-substituted benzimidazole 11 as a potent and selective human formyl peptide receptor-like 1 (hFPRL1) agonist. This compound and its less active enantiomer 12 were identified as useful tools for studying receptor function in
Rapid liquid-phase combinatorial synthesis of heterocyclic libraries.
Chung-Ming Sun
Methods in molecular biology (Clifton, N.J.), 201, 141-166 (2002-10-03)
P Zhang et al.
Bioorganic & medicinal chemistry letters, 11(20), 2747-2750 (2001-10-10)
Novel 6-aryl benzimidazolones and benzothiazolones were prepared and examined as bioisosteres of the recently reported 6-aryl dihydroquinolines (1) for progesterone receptor (PR) antagonist activities. PR antagonist activities increased when compounds 9c-f possessed a more lipophilic group at position-1 and pendent
Hirofumi Omura et al.
Bioorganic & medicinal chemistry letters, 18(11), 3310-3314 (2008-04-29)
Benzimidazolone derivatives were discovered as novel CB2 selective agonists. Structure Activity Relationship (SAR) studies around them were examined to improve metabolic stability. Compound 39 exhibited excellent metabolic stability in human liver microsomes (HLM) and significant attenuation of the chronic colonic
Anna-Maria Monforte et al.
Bioorganic & medicinal chemistry, 17(16), 5962-5967 (2009-07-21)
Non-nucleoside reverse transcriptase inhibitors (NNRTIs) have become very important components in the antiretroviral combination therapies used to treat HIV. Recently, our group identified some 1,3-dihydrobenzimidazol-2-one derivatives and their sulfones as a potent and novel class of NNRTIs. We herein report
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