Application
Triethylamine trihydrofluoride (TREAT-HF) may be employed as a fluorinating reagent for the following studies:
- Microwave-assisted transformation of dichloromethyl- and trichloromethyl substrates to the corresponding fluoro analogs.
- Preparation of 9-(2,3-dideoxy-2-fluoro-β-D-threo-pentofuranosyl)adenine.
- Synthesis of various fluorinated compounds.
- Preparation of fluoroamines.
General description
Triethylamine trihydrofluoride is a non-corrosive reagent. It is a promising source of fluorine and is widely employed in various benzylic fluorination reactions.
signalword
Danger
Hazard Classifications
Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Eye Dam. 1 - Flam. Liq. 2 - Skin Corr. 1A - STOT SE 3
target_organs
Respiratory system
存储类别
3 - Flammable liquids
wgk
WGK 1
flash_point_f
12.2 °F - closed cup
flash_point_c
-11 °C - closed cup
ppe
Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter
法规信息
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Asymmetric Synthesis of Fluoroamines from Chiral Aziridines.
Park H, et al.
Bull. Korean Chem. Soc., 35, 699-700 (2014)
Wei Liu et al.
Angewandte Chemie (International ed. in English), 52(23), 6024-6027 (2013-04-26)
An efficient protocol for the selective fluorination of benzylic C-H bonds is described. The process is catalyzed by manganese salen complexes and uses nucleophilic fluorine sources, such as triethylamine trihydrofluoride and KF. Reaction rates are sufficiently high (30 min) to
Improved synthesis of 9-(2, 3-dideoxy-2-fluoro-β-D-threo-pentofuranosyl) adenine (FddA) using triethylamine trihydrofluoride.
Takamatsu S, et al.
Tetrahedron Letters, 42(12), 2321-2324 (2001)
Microwave-assisted aliphatic fluorine-chlorine exchange using triethylamine trihydrofluoride (TREAT-HF).
Kremsner JM, et al.
Tetrahedron Letters, 50(26), 3665-3668 (2009)
Marcus Gry Björklund et al.
Nucleic acids research, 36(4), 1334-1342 (2008-01-12)
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