方案
99%
表单
liquid
折射率
n20/D 1.449 (lit.)
沸点
113-117 °C (lit.)
密度
1.12 g/mL at 25 °C (lit.)
SMILES字符串
Cc1ccc(F)cc1F
InChI
1S/C7H6F2/c1-5-2-3-6(8)4-7(5)9/h2-4H,1H3
InChI key
MPXDAIBTYWGBSL-UHFFFAOYSA-N
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一般描述
2,4-Difluorotoluene was synthesized as a nucleotide analog and was incorporated into DNA and undergoes replication by DNA polymerase enzymes.
应用
2,4-Difluorotoluene was used in the synthesis of new hydrophobic isosteres of pyrimidines and purine nucleosides.
Eric T Kool et al.
Chemical communications (Cambridge, England), (35)(35), 3665-3675 (2006-10-19)
2,4-Difluorotoluene is unusual among hydrofluorocarbons because it is shaped like the DNA base thymine. It was first synthesised as a nucleotide analogue and incorporated into DNA a decade ago. Although it is a nonpolar molecule, it was found to be
M Todd Washington et al.
Molecular and cellular biology, 23(14), 5107-5112 (2003-07-02)
Classical high-fidelity DNA polymerases discriminate between the correct and incorrect nucleotides by using geometric constraints imposed by the tight fit of the active site with the incipient base pair. Consequently, Watson-Crick (W-C) hydrogen bonding between the bases is not required
Danielle A Pfaff et al.
Journal of the American Chemical Society, 130(14), 4869-4878 (2008-03-18)
The incorporation of synthetic nucleoside analogues into DNA duplexes provides a unique opportunity to probe both structure and function of nucleic acids. We used 1H and 19F NMR and molecular dynamics calculations to determine the solution structures of two similar
Angèle Maki et al.
Nucleic acids research, 31(3), 1059-1066 (2003-02-01)
We report the first experimental probing of electrostatic interactions on the pyrimidine side of a bent A tract. Although the curvature of short A tracts (A4-A6) has long been studied, its physical origins remain under debate. Current hypotheses include the
Thomas W Kirby et al.
Biochemistry, 44(46), 15230-15237 (2005-11-16)
The high fidelity of the DNA polymerization process is critically important for the stability of the cellular genome. The role of template and incoming nucleotide base pairing in polymerase fidelity has recently been explored by the use of nucleotide isosteres
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