135712
2-氯-5-硝基苯甲腈
99%
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关于此项目
线性分子式:
ClC6H3(NO2)CN
化学文摘社编号:
分子量:
182.56
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352100
EC Number:
240-643-6
MDL number:
Assay:
99%
Form:
powder
产品名称
2-氯-5-硝基苯甲腈, 99%
InChI key
ZGILLTVEEBNDOB-UHFFFAOYSA-N
InChI
1S/C7H3ClN2O2/c8-7-2-1-6(10(11)12)3-5(7)4-9/h1-3H
SMILES string
[O-][N+](=O)c1ccc(Cl)c(c1)C#N
assay
99%
form
powder
mp
105-107 °C (lit.)
functional group
chloro
nitrile
nitro
Quality Level
Application
2-Chloro-5-nitrobenzonitrile was used in online detection of rat glutathione S-transferase P1-specific inhibitors by high-resolution screening technology.
General description
2-Chloro-5-nitrobenzonitrile effectively conjugates with rat glutathione S-transferase (GST) isoenzymes and is an alternative model substrate in GST-research.
signalword
Warning
Hazard Classifications
Acute Tox. 4 Dermal - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
Jeroen Kool et al.
Journal of biomolecular screening, 12(3), 396-405 (2007-03-24)
A high-resolution screening (HRS) technology is described, which couples 2 parallel enzyme affinity detection (EAD) systems for substrates and inhibitors of rat cytosolic glutathione-S-transferases (cGSTs) and purified human GST P1 to gradient reversed-phase high-performance liquid chromatography (HPLC). The cGSTs and
E M van der Aar et al.
Xenobiotica; the fate of foreign compounds in biological systems, 26(2), 143-155 (1996-02-01)
1. Four different rat glutathione S-transferase (GST) isoenzymes, belonging to three different classes, were examined for their GSH conjugating capacity towards 11 2-substituted 1-chloro-4-nitrobenzene derivatives. Significant differences were found in their enzyme kinetic parameters Km, kcat and kcat/Km. 2. Substrates
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