表单
powder
质量水平
旋光性
[α]20/D −23°, c = 1 in chloroform
mp
97-99 °C (lit.)
储存温度
2-8°C
SMILES字符串
CC(C)CCC[C@@H](C)[C@H]1CC[C@H]2[C@@H]3CC=C4C[C@@H](S)CC[C@]4(C)[C@H]3CC[C@]12C
InChI
1S/C27H46S/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1
InChI key
QGVQZRDQPDLHHV-DPAQBDIFSA-N
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一般描述
硫代胆固醇是一种与胆固醇相似的脂质，但是羟基被巯基取代。
应用
硫代胆固醇用于生物交联 和膜 研究。
也可作为链转移剂 (CTA) 用于 HPMA 单乳酸盐和 HPMA 二乳酸单体的自由基聚合，形成共聚物。[HPMA = N -（2-羟丙基）甲基丙烯酰胺]
也可作为链转移剂 (CTA) 用于 HPMA 单乳酸盐和 HPMA 二乳酸单体的自由基聚合，形成共聚物。[HPMA = N -（2-羟丙基）甲基丙烯酰胺]
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Zhaohua Huang et al.
Molecular therapy : the journal of the American Society of Gene Therapy, 11(3), 409-417 (2005-02-25)
A series of thiocholesterol-based cationic lipids (TCL) has been designed and synthesized by the attachment of thiocholesterol to a cationic amine via a disulfide bond. TCL can be incorporated into liposomes and used to package DNA into a lipoplex, thereby
M Tanaka et al.
Lipids, 30(4), 321-325 (1995-04-01)
The effect of thiocholesterol (SH-Chol) on the copper-induced in vitro oxidation of low-density lipoprotein (LDL; 1.019 < d < 1.063) was investigated. Among the antioxidants tested, including cysteine, glutathione, 2-mercaptoethanol, dithiothreitol, probucol, thiopalmitic acid, and SH-Chol, SH-Chol was the most
Kun Cheng et al.
The Journal of pharmacology and experimental therapeutics, 317(2), 797-805 (2006-02-03)
A triplex-forming oligonucleotide (TFO) specific for type alpha1(I) collagen promoter is a promising candidate for treating liver fibrosis. Earlier, we determined the pharmacokinetics and biodistribution of TFO after systemic administration into normal and fibrotic rats. In this study, we conjugated
Biochimica et Biophysica Acta, 691, 24-24 (1982)
O Zelphati et al.
Antiviral research, 25(1), 13-25 (1994-09-01)
Encapsulation of oligonucleotides in antibody-targeted liposomes (immunoliposomes) which bind to target cells permits intracellular delivery of the oligonucleotides. This approach circumvents problems of extracellular degradation by nucleases and poor membrane permeability which free phosphodiester oligonucleotides are subject to, but leaves
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