136123
反-查耳酮
97%
别名:
亚苄基代苯乙酮
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关于此项目
线性分子式:
C6H5CH=CHCOC6H5
化学文摘社编号:
分子量:
208.26
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352100
EC Number:
210-383-8
MDL number:
Assay:
97%
Form:
solid
InChI key
DQFBYFPFKXHELB-VAWYXSNFSA-N
InChI
1S/C15H12O/c16-15(14-9-5-2-6-10-14)12-11-13-7-3-1-4-8-13/h1-12H/b12-11+
SMILES string
[H]\C(=C(\[H])C(=O)c1ccccc1)c2ccccc2
assay
97%
form
solid
bp
208 °C/25 mmHg (lit.)
mp
55-57 °C (lit.)
functional group
ketone, phenyl
Quality Level
Gene Information
human ... IL1B(3553)
rat ... Ar(24208)
General description
反式 -查尔酮是一种开链类黄酮，可能预防肺癌和前胃癌。
Application
反式-查尔酮用于合成cis和反式二苯基环丙烷。 它还用于筛选异丁基苯和 4-异丁基苯乙酮的表面吸附物质，用于散装的 Fsfotungstic Wells-Dawson 酸 (H6P2W18O62.xH2O)。
Biochem/physiol Actions
反式-查耳酮具有抗红霉素的抗真菌活性。它是脂肪酸合成酶和α-淀粉酶的抑制剂。由于拟南芥根中线粒体跨膜电位降低，它可诱导程序性细胞死亡。
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Eye Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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Journal of medicinal chemistry, 52(9), 2818-2824 (2009-04-22)
A large series of substituted chalcones have been synthesized and tested in vitro for their ability to inhibit human monoamine oxidases A and B (hMAO-A and hMAO-B). While all the compounds showed hMAO-B selective activity in the micro- and nanomolar
P M Sivakumar et al.
Bioorganic & medicinal chemistry letters, 17(6), 1695-1700 (2007-02-06)
In order to develop relatively small molecules as antimycobacterial agents, twenty-five chalcones were synthesized, their activity was evaluated, and quantitative structure-activity relationship (QSAR) was developed. The synthesis was based on the Claisen-Schimdt scheme and the resultant compounds were tested for
Saeed Attar et al.
Bioorganic & medicinal chemistry, 19(6), 2055-2073 (2011-02-26)
A series of 30 organic chlacones and 33 ferrocenyl (Fc) chalcones were synthesized and characterized by melting point, elemental analysis, spectroscopy ((1)H NMR and FTIR) and, in two cases, by X-ray crystallography. The biological activity of each compound (10(-4)M in
Yi-Kun Chiang et al.
Journal of medicinal chemistry, 52(14), 4221-4233 (2009-06-11)
A pharmacophore model, Hypo1, was built on the basis of 21 training-set indole compounds with varying levels of antiproliferative activity. Hypo1 possessed important chemical features required for the inhibitors and demonstrated good predictive ability for biological activity, with high correlation
Wattenberg L.W., et al.
Cancer Letters, 15, 165-165 (1994)
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