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136123

反-查耳酮

Name: 反-查耳酮
Brand: ALDRICH

97%

别名:

亚苄基代苯乙酮

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关于此项目

线性分子式:

C₆H₅CH=CHCOC₆H₅

化学文摘社编号:

614-47-1

分子量:

208.26

NACRES:

NA.22

PubChem Substance ID:

24848257

UNSPSC Code:

12352100

EC Number:

210-383-8

MDL number:

MFCD00003082

Assay:

97%

Form:

solid

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属性

Quality Level

100

assay

97%

form

solid

bp

208 °C/25 mmHg (lit.)

mp

55-57 °C (lit.)

functional group

ketone, phenyl

SMILES string

[H]\C(=C(\[H])C(=O)c1ccccc1)c2ccccc2

InChI

1S/C15H12O/c16-15(14-9-5-2-6-10-14)12-11-13-7-3-1-4-8-13/h1-12H/b12-11+

InChI key

DQFBYFPFKXHELB-VAWYXSNFSA-N

Gene Information

human ... IL1B(3553)
rat ... Ar(24208)

说明

General description

反式 -查尔酮是一种开链类黄酮，可能预防肺癌和前胃癌。

Application

反式-查尔酮用于合成cis和反式二苯基环丙烷。它还用于筛选异丁基苯和 4-异丁基苯乙酮的表面吸附物质，用于散装的 Fsfotungstic Wells-Dawson 酸 (H₆P₂W₁₈O₆₂.xH₂O)。

Biochem/physiol Actions

反式-查耳酮具有抗红霉素的抗真菌活性。它是脂肪酸合成酶和α-淀粉酶的抑制剂。由于拟南芥根中线粒体跨膜电位降低，它可诱导程序性细胞死亡。

pictograms

GHS07

signalword

Warning

hcodes

H302,H319,H335

pcodes

P261 - P264 - P270 - P271 - P301 + P312 - P305 + P351 + P338

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - STOT SE 3

target_organs

Respiratory system

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Franco Chimenti et al.

Journal of medicinal chemistry, 52(9), 2818-2824 (2009-04-22)

A large series of substituted chalcones have been synthesized and tested in vitro for their ability to inhibit human monoamine oxidases A and B (hMAO-A and hMAO-B). While all the compounds showed hMAO-B selective activity in the micro- and nanomolar

Synthesis, antimycobacterial activity evaluation, and QSAR studies of chalcone derivatives.

P M Sivakumar et al.

Bioorganic & medicinal chemistry letters, 17(6), 1695-1700 (2007-02-06)

In order to develop relatively small molecules as antimycobacterial agents, twenty-five chalcones were synthesized, their activity was evaluated, and quantitative structure-activity relationship (QSAR) was developed. The synthesis was based on the Claisen-Schimdt scheme and the resultant compounds were tested for

Generation of ligand-based pharmacophore model and virtual screening for identification of novel tubulin inhibitors with potent anticancer activity.

Yi-Kun Chiang et al.

Journal of medicinal chemistry, 52(14), 4221-4233 (2009-06-11)

A pharmacophore model, Hypo1, was built on the basis of 21 training-set indole compounds with varying levels of antiproliferative activity. Hypo1 possessed important chemical features required for the inhibitors and demonstrated good predictive ability for biological activity, with high correlation

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全球贸易项目编号

货号	GTIN
136123-5G	04061838731159
136123-100G	04061838731142