141186
特戊酸氯甲酯
97%
别名:
POM-Cl, 新戊酸氯甲酯
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关于此项目
线性分子式:
(CH3)3CCOOCH2Cl
化学文摘社编号:
分子量:
150.60
UNSPSC Code:
12352100
NACRES:
NA.22
PubChem Substance ID:
EC Number:
242-735-1
Beilstein/REAXYS Number:
1560838
MDL number:
产品名称
特戊酸氯甲酯, 97%
InChI key
GGRHYQCXXYLUTL-UHFFFAOYSA-N
InChI
1S/C6H11ClO2/c1-6(2,3)5(8)9-4-7/h4H2,1-3H3
SMILES string
CC(C)(C)C(=O)OCCl
assay
97%
form
liquid
refractive index
n20/D 1.417 (lit.)
bp
146-148 °C (lit.)
density
1.045 g/mL at 25 °C (lit.)
functional group
chloro
ester
Quality Level
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Application
新戊酸氯甲酯可作为前提药物，用于合成氧氟沙星中的新戊酰氧基甲酯。通过微波辅助、连续流动的有机合成，可将其用作异吲哚啉环化的三环磺胺文库合成过程中的试剂。
General description
新戊酸氯甲酯可与舒巴坦的钠盐反应生成舒巴坦匹酯。它可与9-（2-膦酰基甲氧基乙基）腺嘌呤（PMEA）进行酰化反应得到 双（新戊酰氧基甲基）PMEA。
signalword
Warning
Hazard Classifications
Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Flam. Liq. 3 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
3 - Flammable liquids
wgk
WGK 3
flash_point_f
104.0 °F - closed cup
flash_point_c
40 °C - closed cup
ppe
Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
法规信息
危险化学品
此项目有
J E Starrett et al.
Antiviral research, 19(3), 267-273 (1992-09-11)
9-(2-Phosphonylmethoxyethyl)adenine (PMEA; 1) was acylated with chloromethyl pivalate to afford bis(pivaloyloxymethyl) PMEA (2). The ester prodrug demonstrated enhanced in vitro potency against HSV-2 greater than 150-fold higher than the parent compound. The antiviral activity of 2 was 50-fold better than
L S Changov et al.
Farmaco (Societa chimica italiana : 1989), 55(2), 134-135 (2000-04-27)
Sulbactam pivoxil, a prodrug of the beta-lactamase inhibitor sulbactam, was prepared in high yield by reacting the sodium salt of sulbactam with chloromethyl pivalate in a polar solvent, then diluting the reaction mixture with water and isolating the product by
Farman Ullah et al.
Synthesis, 44(16), doi:10-doi:10 (2012-01-01)
A microwave-assisted, continuous-flow organic synthesis (MACOS) protocol for the synthesis of an isoindoline-annulat-ed, tricyclic sultam library, utilizing a Heck-aza-Michael (HaM) strategy, is reported. This sequence involves a Heck reaction on vi-nylsulfonamides with batch microwave heating followed by a one-pot, sequential
Y Maeda et al.
Biological & pharmaceutical bulletin, 16(6), 594-599 (1993-06-01)
We newly synthesized a pivaloyloxymethyl ester of ofloxacin (OFLX-PVM) as prodrug in order to avoid the chelate formation between new quinolone and metal cations such as Al3+, Mg2+, Ca2+, or Fe2+ in the gastrointestinal tract. This compound was rapidly hydrolyzed
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