142360
4-苄基哌啶
99%
别名:
苯基(4-哌啶基)甲烷
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选择尺寸
关于此项目
经验公式（希尔记法）:
C12H17N
化学文摘社编号:
分子量:
175.27
UNSPSC Code:
12352100
NACRES:
NA.22
PubChem Substance ID:
EC Number:
250-535-0
Beilstein/REAXYS Number:
132339
MDL number:
Assay:
99%
产品名称
4-苄基哌啶, 99%
InChI key
ABGXADJDTPFFSZ-UHFFFAOYSA-N
InChI
1S/C12H17N/c1-2-4-11(5-3-1)10-12-6-8-13-9-7-12/h1-5,12-13H,6-10H2
SMILES string
C1CC(CCN1)Cc2ccccc2
description
Drug Control: Pszichotróp anyag / Psychotropic Substance (Hungary), 78/2022. (XII. 28.) BM rendelet
assay
99%
drug control
Pszichotróp anyag / Psychotropic Substance (Hungary), 78/2022. (XII. 28.) BM rendelet
refractive index
n20/D 1.537 (lit.)
bp
279 °C (lit.)
mp
6-7 °C (lit.)
density
0.997 g/mL at 25 °C (lit.)
functional group
phenyl
Quality Level
Gene Information
rat ... Htr2a(29595), Htr2c(25187)
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Application
4-苄基哌啶被用于研究雄性B6C3F1小鼠和Sprague-Dawley大鼠的灌注肝脏中1,3-丁二烯及其氧化代谢产物的代谢。
用于合成以下物质的反应物：
- 抗增殖剂
- GABA吸收抑制剂
- 吡啶类
- 组胺 H3 拮抗剂
- 具有胆碱能和神经保护作用的多功能药物，可用于治疗阿尔茨海默氏症和神经血管疾病
- 通过亲核取代，发挥抗血清素、抗血小板、血液流变学、抗心律失常和抗氧化作用
Biochem/physiol Actions
4-苄基哌啶能够抑制大鼠脑单胺氧化酶-A和-B的活性。
General description
4-苄基哌啶是多巴胺选择性释放剂。它是治疗可卡因成瘾的潜在候选药物。
存储类别
10 - Combustible liquids
wgk
WGK 3
flash_point_f
233.6 °F - closed cup
flash_point_c
112 °C - closed cup
ppe
Eyeshields, Gloves, type ABEK (EN14387) respirator filter
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Y Arai et al.
Neuroscience letters, 70(2), 255-260 (1986-10-08)
Inhibitory effects of some MPTP and MPP+ analogues on rat brain MAO activity were studied to further clarify the structure-activity relationships of MPTP neurotoxicity. Of the analogues tested, 4-(4-chlorophenyl)-1,2,3,6-tetrahydropyridine (CPTP), 4-(4-chlorobenzyl)-pyridine (CBP), 4-benzylpyridine (BPY) and 4-benzylpiperidine (BPIP) dose-dependently inhibited both
Johannes G Filser et al.
Toxicological sciences : an official journal of the Society of Toxicology, 114(1), 25-37 (2009-12-17)
The industrial chemical 1,3-butadiene (BD) is a potent carcinogen in mice and a weak one in rats. This difference is generally related to species-specific burdens by the metabolites 1,2-epoxy-3-butene (EB), 1,2:3,4-diepoxybutane (DEB), and 3,4-epoxy-1,2-butanediol (EBD), which are all formed in
S S Negus et al.
The Journal of pharmacology and experimental therapeutics, 329(1), 272-281 (2009-01-20)
Monoamine releasers constitute one class of drugs currently under investigation as potential agonist medications for the treatment of cocaine dependence. The efficacy and safety of monoamine releasers as candidate medications may be influenced in part by their relative potency to
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