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142360

4-苄基哌啶

Name: 4-苄基哌啶
Brand: ALDRICH

99%

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别名:

苯基(4-哌啶基)甲烷

经验公式（希尔记法）:

C₁₂H₁₇N

CAS号:

31252-42-3

分子量:

175.27

Beilstein:

132339

EC 号:

250-535-0

MDL编号:

MFCD00006006

PubChem化学物质编号:

24848521

NACRES:

NA.22

检测方案

99%

折射率

n20/D 1.537 (lit.)

bp

279 °C (lit.)

mp

6-7 °C (lit.)

密度

0.997 g/mL at 25 °C (lit.)

SMILES string

C1CC(CCN1)Cc2ccccc2

InChI

1S/C12H17N/c1-2-4-11(5-3-1)10-12-6-8-13-9-7-12/h1-5,12-13H,6-10H2

InChI key

ABGXADJDTPFFSZ-UHFFFAOYSA-N

Gene Information

rat ... Htr2a(29595) , Htr2c(25187)

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一般描述

4-苄基哌啶是多巴胺选择性释放剂。它是治疗可卡因成瘾的潜在候选药物。

应用

4-苄基哌啶被用于研究雄性B6C3F1小鼠和Sprague-Dawley大鼠的灌注肝脏中1,3-丁二烯及其氧化代谢产物的代谢。

用于合成以下物质的反应物：

抗增殖剂
GABA吸收抑制剂
吡啶类
组胺 H3 拮抗剂
具有胆碱能和神经保护作用的多功能药物，可用于治疗阿尔茨海默氏症和神经血管疾病
通过亲核取代，发挥抗血清素、抗血小板、血液流变学、抗心律失常和抗氧化作用

生化/生理作用

4-苄基哌啶能够抑制大鼠脑单胺氧化酶-A和-B的活性。

储存分类代码

10 - Combustible liquids

WGK

WGK 3

闪点(°F)

233.6 °F - closed cup

闪点(°C)

112 °C - closed cup

个人防护装备

Eyeshields, Gloves, type ABEK (EN14387) respirator filter

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示例

T1503

货号

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Sindhu S Ganti et al.

International journal of pharmaceutics, 550(1-2), 71-78 (2018-08-21)

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Quantitative investigation on the metabolism of 1,3-butadiene and of its oxidized metabolites in once-through perfused livers of mice and rats.

Johannes G Filser et al.

Toxicological sciences : an official journal of the Society of Toxicology, 114(1), 25-37 (2009-12-17)

The industrial chemical 1,3-butadiene (BD) is a potent carcinogen in mice and a weak one in rats. This difference is generally related to species-specific burdens by the metabolites 1,2-epoxy-3-butene (EB), 1,2:3,4-diepoxybutane (DEB), and 3,4-epoxy-1,2-butanediol (EBD), which are all formed in

Time-dependent inhibition of rat brain monoamine oxidase by an analogue of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), 4-(4-chlorophenyl)-1,2,3,6-tetrahydropyridine.

Y Arai et al.

Neuroscience letters, 70(2), 255-260 (1986-10-08)

Inhibitory effects of some MPTP and MPP+ analogues on rat brain MAO activity were studied to further clarify the structure-activity relationships of MPTP neurotoxicity. Of the analogues tested, 4-(4-chlorophenyl)-1,2,3,6-tetrahydropyridine (CPTP), 4-(4-chlorobenzyl)-pyridine (CBP), 4-benzylpyridine (BPY) and 4-benzylpiperidine (BPIP) dose-dependently inhibited both

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S S Negus et al.

The Journal of pharmacology and experimental therapeutics, 329(1), 272-281 (2009-01-20)

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