142662
氯磺酰异氰酸酯
98%
别名:
N-碳酰氨磺酰基氯, CSI
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关于此项目
线性分子式:
ClSO2NCO
化学文摘社编号:
分子量:
141.53
UNSPSC Code:
12352100
NACRES:
NA.22
PubChem Substance ID:
EC Number:
214-715-2
Beilstein/REAXYS Number:
1237247
MDL number:
产品名称
氯磺酰异氰酸酯, 98%
InChI key
WRJWRGBVPUUDLA-UHFFFAOYSA-N
InChI
1S/CClNO3S/c2-7(5,6)3-1-4
SMILES string
ClS(=O)(=O)N=C=O
vapor pressure
5.57 psi ( 20 °C)
assay
98%
form
liquid
refractive index
n20/D 1.447 (lit.)
bp
107 °C (lit.)
mp
−44 °C (lit.)
density
1.626 g/mL at 25 °C (lit.)
storage temp.
2-8°C
Quality Level
Gene Information
human ... ABCB1(5243), FPR1(2357)
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Application
- 氯磺酰基异氰酸酯被用于新型膜相关糖基转移酶抑制剂的合成和生化表征。
- 它是一种合成上用途广泛的试剂，被用于酰胺类、内酰胺类和三唑辛酮类的制备。
- 在手性多羟基哌啶的合成中，它被用于保护氨基的区域和非对映选择性引入。
- 在新的磺酰胺类化合物的合成中用作试剂 。
在手性多羟基哌啶的合成中，用于保护氨基的区域和非对映选择性引入。在苯并咪唑酮合成中，从氨基生成尿素。
General description
氯磺酰异氰酸酯属于异氰酸酯，被广泛用于磺酰化和氨基甲酰化反应的试剂。氯磺酰异氰酸酯与烯烃通过逐步偶极途径反应生成C N-氯磺酰-β-内酰胺。
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Eye Dam. 1 - Resp. Sens. 1 - Skin Corr. 1B - Skin Sens. 1
supp_hazards
存储类别
8A - Combustible corrosive hazardous materials
wgk
WGK 3
flash_point_f
>230.0 °F
flash_point_c
> 110 °C
ppe
Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter
Synthetic Communications, 22, 2729-2729 (1992)
P Paul et al.
The Journal of biological chemistry, 268(17), 12933-12938 (1993-06-15)
A new class of compounds designed to inhibit membrane-associated glycosyltransferases were synthesized and their biological activities were characterized in liver microsomes and human lymphoma cell lines. These inhibitors are composed of N-acyl phenylaminoalcohol derivatives linked to uridine via different spacers.
Dale F Shellhamer et al.
The Journal of organic chemistry, 78(2), 246-252 (2012-12-15)
Chlorosulfonyl isocyanate (CSI) is reported to react with hydrocarbon alkenes by a stepwise dipolar pathway to give N-chlorosulfonyl-β-lactams that are readily reduced to β-lactams. Substitution of a vinyl hydrogen for a vinyl fluorine changes the dynamics for reaction with CSI
Synthesis and antibacterial activity of sulfonamides. SAR and DFT studies
Boufas, Wahida et al.
Journal of Molecular Structure, 180-185 (2014)
Synthetic Communications, 23, 2151-2151 (1993)
实验方案
Optimize β-glucuronidase hydrolysis for glucuronide metabolite analysis considering factors like time, temperature, pH, and enzyme concentration.
为了使用β-葡糖醛酸酶优化水解，必须对每种待分析的葡糖苷酸代谢物进行某些因素的评估，例如孵育时间、温度、水解pH、酶源和酶浓度。
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