142859
二氟乙酸
98%
别名:
1,1-Difluoroacetic acid, 2,2-Difluoroacetic acid
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线性分子式:
F2CHCO2H
化学文摘社编号:
分子量:
96.03
UNSPSC Code:
12352106
NACRES:
NA.22
PubChem Substance ID:
EC Number:
206-839-0
Beilstein/REAXYS Number:
1098588
MDL number:
Assay:
98%
Form:
liquid
产品名称
二氟乙酸, 98%
InChI key
PBWZKZYHONABLN-UHFFFAOYSA-N
InChI
1S/C2H2F2O2/c3-1(4)2(5)6/h1H,(H,5,6)
SMILES string
OC(=O)C(F)F
assay
98%
form
liquid
refractive index
n20/D 1.344 (lit.)
bp
132-134 °C (lit.)
mp
−1 °C (lit.)
density
1.526 g/mL at 25 °C (lit.)
functional group
carboxylic acid
fluoro
Quality Level
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Application
用于在三苯基膦的介导下，由邻位取代苯胺制备 2-二氟化甲基苯并咪唑、-噁唑和-噻唑。
General description
二氟乙酸是一种单羧酸，也是一种有机氟化合物。二氟乙酸是一种易于操作的试剂，用于制备二氟甲基取代基。二氟乙酸可用作直接对杂环化合物进行C−H二氟甲基化的二氟甲基化试剂。
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 4 Inhalation - Aquatic Chronic 3 - Eye Dam. 1 - Skin Corr. 1A
存储类别
8A - Combustible corrosive hazardous materials
wgk
WGK 3
flash_point_f
172.4 °F - closed cup
flash_point_c
78 °C - closed cup
ppe
Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter
Gaëlle Blond et al.
Chemistry (Weinheim an der Bergstrasse, Germany), 8(13), 2917-2922 (2002-12-20)
Ethers of trifluoroacetaldehyde hemiaminals can undergo dehydrofluorination under basic conditions to provide ethers of difluoroketene hemiaminals. The latter behave as equivalents of difluoroacetamide or difluoroacetate anions towards various electrophiles, yielding a range of difluoromethylcarbonyl products.
Hoffman B M Lantum et al.
Toxicological sciences : an official journal of the Society of Toxicology, 70(2), 261-268 (2002-11-21)
Dichloroacetic acid (DCA), chlorofluoroacetic acid (CFA), and difluoroacetic acid (DFA) are inhibitors of pyruvate dehydrogenase kinase. DCA is used for the clinical management of congenital lactic acidosis. Glutathione transferase zeta (GSTZ1-1) catalyzes the biotransformation of DCA and CFA, and DCA
J M Dalstein et al.
Comptes rendus des seances de la Societe de biologie et de ses filiales, 174(5), 821-825 (1980-01-01)
In the anesthetized rat, the intraperitoneal injection of 40 mg/kg sodium difluoroacetate (DFA), an activator of the pyruvate dehydrogenase, counteracted the hyperlactatemia induced by a high dose of phenformin (40 mg/kg) injected concomitantly. In the normal conscious dog, the administration
J N Commandeur et al.
Biochemical pharmacology, 37(23), 4495-4504 (1988-12-01)
The biotransformation and the hepato- and nephrotoxicity of the mercapturic acids (N-acetyl-1-cysteine S-conjugates) of three structurally related 2,2-difluoroethylenes were investigated in vivo in the rat. All mercapturic acids appeared to cause nephrotoxicity, without any measureable effect on the liver. The
Ute Dorgerloh et al.
Molecules (Basel, Switzerland), 24(6) (2019-03-17)
The concentrations of difluoroacetic acid (DFA) and trifluoroacetic acid (TFA) in rainwater and surface water from Berlin, Germany resembled those reported for similar urban areas, and the TFA/DFA ratio in rainwater of 10:1 was in accordance with the literature. In
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