142859
二氟乙酸
98%
别名:
1,1-Difluoroacetic acid, 2,2-Difluoroacetic acid
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关于此项目
线性分子式:
F2CHCO2H
化学文摘社编号:
分子量:
96.03
UNSPSC Code:
12352106
NACRES:
NA.22
PubChem Substance ID:
EC Number:
206-839-0
Beilstein/REAXYS Number:
1098588
MDL number:
Assay:
98%
Form:
liquid
Quality Level
assay
98%
form
liquid
refractive index
n20/D 1.344 (lit.)
bp
132-134 °C (lit.)
mp
−1 °C (lit.)
density
1.526 g/mL at 25 °C (lit.)
functional group
carboxylic acid, fluoro
SMILES string
OC(=O)C(F)F
InChI
1S/C2H2F2O2/c3-1(4)2(5)6/h1H,(H,5,6)
InChI key
PBWZKZYHONABLN-UHFFFAOYSA-N
General description
二氟乙酸是一种单羧酸，也是一种有机氟化合物。二氟乙酸是一种易于操作的试剂，用于制备二氟甲基取代基。二氟乙酸可用作直接对杂环化合物进行C−H二氟甲基化的二氟甲基化试剂。
Application
用于在三苯基膦的介导下，由邻位取代苯胺制备 2-二氟化甲基苯并咪唑、-噁唑和-噻唑。
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signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 4 Inhalation - Aquatic Chronic 3 - Eye Dam. 1 - Skin Corr. 1A
存储类别
8A - Combustible corrosive hazardous materials
wgk
WGK 3
flash_point_f
172.4 °F - closed cup
flash_point_c
78 °C - closed cup
ppe
Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter
Gaëlle Blond et al.
Chemistry (Weinheim an der Bergstrasse, Germany), 8(13), 2917-2922 (2002-12-20)
Ethers of trifluoroacetaldehyde hemiaminals can undergo dehydrofluorination under basic conditions to provide ethers of difluoroketene hemiaminals. The latter behave as equivalents of difluoroacetamide or difluoroacetate anions towards various electrophiles, yielding a range of difluoromethylcarbonyl products.
J M Dalstein et al.
Comptes rendus des seances de la Societe de biologie et de ses filiales, 174(5), 821-825 (1980-01-01)
In the anesthetized rat, the intraperitoneal injection of 40 mg/kg sodium difluoroacetate (DFA), an activator of the pyruvate dehydrogenase, counteracted the hyperlactatemia induced by a high dose of phenformin (40 mg/kg) injected concomitantly. In the normal conscious dog, the administration
Hoffman B M Lantum et al.
Toxicological sciences : an official journal of the Society of Toxicology, 70(2), 261-268 (2002-11-21)
Dichloroacetic acid (DCA), chlorofluoroacetic acid (CFA), and difluoroacetic acid (DFA) are inhibitors of pyruvate dehydrogenase kinase. DCA is used for the clinical management of congenital lactic acidosis. Glutathione transferase zeta (GSTZ1-1) catalyzes the biotransformation of DCA and CFA, and DCA
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| 142859-25G | 04061838118004 |
| 142859-5G | 04061838734501 |