143057
Aldrithiol™-4
98%
别名:
4,4′-二吡啶基二硫醚, 4,4′-二硫二吡啶
质量水平
方案
98%
表单
solid
mp
76-78 °C (lit.)
溶解性
95% ethanol: soluble 5%, clear, colorless to light yellow
官能团
disulfide
储存温度
2-8°C
SMILES字符串
S(Sc1ccncc1)c2ccncc2
InChI
1S/C10H8N2S2/c1-5-11-6-2-9(1)13-14-10-3-7-12-8-4-10/h1-8H
InChI key
UHBAPGWWRFVTFS-UHFFFAOYSA-N
应用
- Aldrithiol ™-4 在一项研究中被用作共底物,通过 体外进化技术 :噬菌体展示 开发出针对甘露糖结合凝集素相关丝氨酸蛋白酶的高度特异性抑制剂。
- 用于研究在接近生理条件下测定的重组人脑红蛋白和细胞红蛋白的 O2 平衡 。
- 用于修饰蛋白研究的金表面 。
法律信息
Aldrithiol is a trademark of Sigma-Aldrich Co. LLC
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
F Peter Guengerich et al.
Biochemistry, 42(37), 10965-10970 (2003-09-17)
The active site cysteine of human O(6)-alkylguanine-DNA alkyltransferase (hAGT), Cys145, was shown to be highly reactive with model electrophiles unrelated to substrates, including 1-chloro-2,4-dinitrobenzene. The high reactivity suggested that the Cys145 thiolate anion might be stable at neutral pH. The
Iveta Imriskova-Sosova et al.
Biochemistry, 44(51), 16949-16956 (2005-12-21)
Members of the Sco protein family are implicated in the assembly of the respiratory complex cytochrome c oxidase. Several possible roles have been proposed for Sco: a copper delivery agent, a site-specific thiol reductase, and an indicator of cellular redox
Soong-Yu Kuo et al.
Archives of toxicology, 77(11), 630-637 (2003-08-21)
The effect of oxidants on Ca(2+) movement in osteoblasts is unclear. In this study, we show that 4,4'-dithiodipyridine (4,4'-DTDP), a reactive disulphide that mobilizes Ca(2+) in muscle, induces an increase in cytoplasmic free-Ca(2+) concentrations ([Ca(2+)](i)) in MG63 human osteosarcoma cells
H Reynaldo López-Mirabal et al.
FEMS yeast research, 7(3), 391-403 (2007-01-27)
Dipyridyl disulfide (DPS) is a highly reactive thiol oxidant that functions as electron acceptor in thiol-disulfide exchange reactions. DPS is very toxic to yeasts, impairing growth at low micromolar concentrations. The genes TRX2 (thioredoxin), SOD1 (superoxide dismutase), GSH1 (gamma-glutamyl-cysteine synthetase)
J. Vac. Sci. Technol. B, 12, 1486-1486 (1994)
商品
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Clostridium perfringens can cause contamination in undercooked or improperly sterilized canned foods and water. Learn to detect, identify, and differentiate this pathogen.
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