143057
Aldrithiol™-4
98%
别名:
4,4′-二吡啶基二硫醚, 4,4′-二硫二吡啶
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关于此项目
经验公式（希尔记法）:
C10H8N2S2
化学文摘社编号:
分子量:
220.31
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352100
EC Number:
220-158-6
MDL number:
产品名称
Aldrithiol™-4, 98%
InChI key
UHBAPGWWRFVTFS-UHFFFAOYSA-N
InChI
1S/C10H8N2S2/c1-5-11-6-2-9(1)13-14-10-3-7-12-8-4-10/h1-8H
SMILES string
S(Sc1ccncc1)c2ccncc2
assay
98%
form
solid
mp
76-78 °C (lit.)
solubility
95% ethanol: soluble 5%, clear, colorless to light yellow
functional group
disulfide
storage temp.
2-8°C
Quality Level
Application
- Aldrithiol ™-4 在一项研究中被用作共底物，通过 体外进化技术 ：噬菌体展示 开发出针对甘露糖结合凝集素相关丝氨酸蛋白酶的高度特异性抑制剂。
- 用于研究在接近生理条件下测定的重组人脑红蛋白和细胞红蛋白的 O2 平衡 。
- 用于修饰蛋白研究的金表面 。
Legal Information
Aldrithiol is a trademark of Sigma-Aldrich Co. LLC
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
J. Vac. Sci. Technol. B, 12, 1486-1486 (1994)
Soong-Yu Kuo et al.
Archives of toxicology, 77(11), 630-637 (2003-08-21)
The effect of oxidants on Ca(2+) movement in osteoblasts is unclear. In this study, we show that 4,4'-dithiodipyridine (4,4'-DTDP), a reactive disulphide that mobilizes Ca(2+) in muscle, induces an increase in cytoplasmic free-Ca(2+) concentrations ([Ca(2+)](i)) in MG63 human osteosarcoma cells
H Reynaldo López-Mirabal et al.
FEMS yeast research, 7(3), 391-403 (2007-01-27)
Dipyridyl disulfide (DPS) is a highly reactive thiol oxidant that functions as electron acceptor in thiol-disulfide exchange reactions. DPS is very toxic to yeasts, impairing growth at low micromolar concentrations. The genes TRX2 (thioredoxin), SOD1 (superoxide dismutase), GSH1 (gamma-glutamyl-cysteine synthetase)
Rosa E Hansen et al.
Analytical biochemistry, 363(1), 77-82 (2007-02-09)
Experimental determination of the number of thiols in a protein requires methodology that combines high sensitivity and reproducibility with low intrinsic thiol oxidation disposition. In detection of disulfide bonds, it is also necessary to efficiently reduce disulfides and to quantify
Hong Xie et al.
Biophysical journal, 91(8), 2882-2891 (2006-08-01)
To understand better the modulation of ryanodine receptors (RyRs) during oxidative stress, the effect of 4,4'-dithiodipyridine (DTDP), a cell-permeant and thiol-reactive oxidant, on global Ca(2+) signal and spontaneous Ca(2+) sparks of rat ventricular myocytes was investigated. It was shown that
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