144436
异丁酰胺
99%
别名:
2-甲基丙酰胺
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关于此项目
线性分子式:
(CH3)2CHCONH2
化学文摘社编号:
分子量:
87.12
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352100
EC Number:
209-265-9
MDL number:
Assay:
99%
Form:
solid
InChI key
WFKAJVHLWXSISD-UHFFFAOYSA-N
InChI
1S/C4H9NO/c1-3(2)4(5)6/h3H,1-2H3,(H2,5,6)
SMILES string
CC(C)C(N)=O
assay
99%
form
solid
bp
216-220 °C (lit.)
mp
127-131 °C (lit.)
density
1.013 g/mL at 25 °C (lit.)
functional group
amide
Quality Level
Application
异丁酰胺在合成过程中用于人血清白蛋白的化学接枝序列组装蛋白胶囊 。
Biochem/physiol Actions
异丁酰胺激活人 γ-珠蛋白基因和鼠胚胎 ε（y）-珠蛋白基因的转录 。它可用于治疗 β-地中海贫血和镰状细胞病 。
M E Gleave et al.
Journal of cellular biochemistry, 69(3), 271-281 (1998-05-15)
Progression to androgen independence remains the main obstacle to improving survival and quality of life in patients with advanced prostate cancer. Induction of differentiation may serve as a rational basis for prevention of progression to androgen independence by modulating gene
S Reich et al.
Blood, 96(10), 3357-3363 (2000-11-09)
The butyrate derivative isobutyramide (IBT) increases fetal hemoglobin (HbF) in patients with beta-hemoglobinopathies, but little is known about its usefulness for prolonged therapeutic use. We treated 8 patients with transfusion-dependent beta-thalassemia with 350 mg/kg of body weight per day of
Thermosensitive molecular assemblies from poly(amidoamine) dendron-based lipids.
Kenji Kono et al.
Angewandte Chemie (International ed. in English), 50(28), 6332-6336 (2011-05-21)
J Zhang et al.
Chinese medical sciences journal = Chung-kuo i hsueh k'o hsueh tsa chih, 16(4), 187-193 (2003-08-09)
To examine the effect of isobutyramide synthesized in our laboratory on human and murine globin gene expression and to test cell toxicity of the drug. MEL cells were transfected with the recombinant construct muLCRAgammapsibetadeltabeta and the stable transformants were cultured
S P Perrine et al.
The American journal of pediatric hematology/oncology, 16(1), 67-71 (1994-02-01)
Stimulating expression of the normal fetal globin genes is a preferred method of ameliorating sickle cell disease and beta-thalassemia for the majority of patients in North America who do not have appropriate bone marrow donors. Due to increased survival of
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