质量水平
方案
99%
表单
solid
沸点
216-220 °C (lit.)
mp
127-131 °C (lit.)
密度
1.013 g/mL at 25 °C (lit.)
官能团
amide
SMILES字符串
CC(C)C(N)=O
InChI
1S/C4H9NO/c1-3(2)4(5)6/h3H,1-2H3,(H2,5,6)
InChI key
WFKAJVHLWXSISD-UHFFFAOYSA-N
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应用
异丁酰胺在合成过程中用于人血清白蛋白的化学接枝序列组装蛋白胶囊 。
生化/生理作用
异丁酰胺激活人 γ-珠蛋白基因和鼠胚胎 ε（y）-珠蛋白基因的转录 。它可用于治疗 β-地中海贫血和镰状细胞病 。
M Domenica Cappellini et al.
Blood cells, molecules & diseases, 26(1), 105-111 (2000-04-25)
A pilot phase II open study on 12 patients with thalassemia intermedia (7 men, 5 women; age 31 +/- 2.0 years SE) treated with oral isobutyramide, a derivative of butyric acid (150 mg/kg body wt/day), was performed in order to
Damien Mertz et al.
Advanced materials (Deerfield Beach, Fla.), 23(47), 5668-5673 (2011-11-22)
Bromoisobutyramide (BrIBAM)-modified silica templates facilitate the formation of bio-functional thin films made of a range of biopolymers (e.g., polypeptides, nucleic acids or polysaccharides). Upon template removal, non-covalent free-standing biopolymeric assemblies (e.g., hollow capsules or replicated spheres and fibers) are formed
D Toptygin et al.
Analytical biochemistry, 224(1), 330-338 (1995-01-01)
A new computational approach for the analysis of equilibrium binding data obtained by spectroscopic methods is described. The approach is aimed at systems involving multiple interactions, where the changes in the spectroscopic signal cannot be attributed to a single interaction.
M J Haas et al.
Journal of molecular endocrinology, 25(1), 129-139 (2000-07-29)
To determine if ketoacidosis contributes to reduced apolipoprotein A1 (apoA1) expression in insulin-deficient diabetic rats, we examined the regulation of apoA1 gene expression in response to changes in ambient pH or ketone body concentrations. Hepatic apoAI mRNA levels were reduced
S P Perrine et al.
Experientia, 49(2), 133-137 (1993-02-15)
The inherited beta-hemoglobinopathies (sickle cell disease and beta thalassemia) are the result of a mutation in the adult (beta) globin gene. The fetal globin chain, encoded by the gamma globin genes, can substitute for the mutated or defective beta globin
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