151637
异噁唑
99%
别名:
1,2-Oxazole, 1-Oxa-2-azacyclopentadiene, 2-Azafuran
蒸汽密度
2.4 (vs air)
质量水平
方案
99%
表单
liquid
折射率
n20/D 1.427 (lit.)
沸点
93-95 °C (lit.)
密度
1.078 g/mL at 25 °C (lit.)
储存温度
2-8°C
SMILES字符串
c1cnoc1
InChI
1S/C3H3NO/c1-2-4-5-3-1/h1-3H
InChI key
CTAPFRYPJLPFDF-UHFFFAOYSA-N
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一般描述
Isoxazole are described as inhibitors of acetylcholinesterase (AChE). Isoxazole ligands bind to and inhibit the Sxc- antiporter.
Sahaya Asirvatham et al.
Anti-inflammatory & anti-allergy agents in medicinal chemistry, 14(2), 128-137 (2015-08-13)
A series of newer 3-(4'-methoxyphenyl)-5-substituted phenylisoxazoles derivatives have been synthesized by reacting hydroxylamine hydrochloride with chalcones. The chalcones were formed by reacting different aromatic aldehydes with 4-methoxyacetophenone in presence of aqueos potassium hydroxide (KOH). The purity of all the synthesized
Cesira de Chiara et al.
Nature chemical biology, 16(6), 686-694 (2020-03-24)
The broad-spectrum antibiotic D-cycloserine (DCS) is a key component of regimens used to treat multi- and extensively drug-resistant tuberculosis. DCS, a structural analog of D-alanine, binds to and inactivates two essential enzymes involved in peptidoglycan biosynthesis, alanine racemase (Alr) and
Nikolai V Rostovskii et al.
The Journal of organic chemistry, 82(1), 256-268 (2016-12-16)
4-Aminopyrrole-3-carboxylates and pyrazine-2-carboxylates were synthesized from 5-alkoxyisoxazoles and 1-sulfonyl-1,2,3-triazoles by tuning the Rh(II) catalyst and the reaction conditions. The reaction in chloroform at 100 °C under Rh
Adam A Wallace et al.
The journal of physical chemistry. A, 124(38), 7768-7775 (2020-08-28)
We report a photoelectron imaging study of gas-phase deprotonation of isoxazole in which spectroscopic data are compared to the results of electronic structure calculations for the anion products corresponding to each of three possible deprotonation sites. The observed photoelectron spectra
Afnan A Matti et al.
Bioorganic & medicinal chemistry letters, 23(21), 5931-5935 (2013-09-18)
Microwave accelerated reaction system (MARS) technology provided a good method to obtain selective and open isoxazole ligands that bind to and inhibit the Sxc- antiporter. The MARS provided numerous advantages, including: shorter time, better yield and higher purity of the
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