155268
(R)-(+)-α-甲氧基-α-三氟甲基苯乙酸
99%
别名:
(+)-MTPA, Mosher 酸
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关于此项目
线性分子式:
C6H5C(OCH3)(CF3)CO2H
化学文摘社编号:
分子量:
234.17
UNSPSC Code:
12352112
NACRES:
NA.22
PubChem Substance ID:
EC Number:
243-829-5
Beilstein/REAXYS Number:
3591560
MDL number:
产品名称
(R)-(+)-α-甲氧基-α-三氟甲基苯乙酸, 99%
InChI key
JJYKJUXBWFATTE-SECBINFHSA-N
InChI
1S/C10H9F3O3/c1-16-9(8(14)15,10(11,12)13)7-5-3-2-4-6-7/h2-6H,1H3,(H,14,15)/t9-/m1/s1
SMILES string
CO[C@@](C(O)=O)(c1ccccc1)C(F)(F)F
assay
99%
form
solid
optical activity
[α]20/D +72°, c = 1.6 in methanol
optical purity
ee: 99% (GLC)
refractive index
n20/D 1.473 (lit.)
bp
105-107 °C/1 mmHg (lit.)
mp
46-49 °C (lit.)
density
1.344 g/mL at 25 °C (lit.)
functional group
carboxylic acid
ether
fluoro
phenyl
storage temp.
2-8°C
Quality Level
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Application
(R)-(+)-α-Methoxy-α-trifluoromethylphenylacetic acid is commonly used as a derivatizing agent in Mosher ester analysis, an NMR-based method for determining the absolute configuration of the chiral carbon center in a secondary alcohol.
Other Notes
doi:10.1038/nprot.2007.354
Packaging
Bottomless glass bottle. Contents are inside inserted fused cone.
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
235.4 °F - closed cup
flash_point_c
113 °C - closed cup
ppe
dust mask type N95 (US), Eyeshields, Gloves
Tetrahedron Asymmetry, 18, 975-975 (2007)
Lidia De Luca et al.
The Journal of organic chemistry, 72(10), 3955-3957 (2007-04-11)
An effective route to chiral optically active 2-substituted benzofurans directly from carboxylic acids is reported. This procedure, which allows the preparation of alpha-alkyl-2-benzofuranmethanamines from N-protected alpha-amino acids without sensible racemization phenomena, proceeds in good yields under mild conditions with the
Mosher ester analysis for the determination of absolute configuration of stereogenic (chiral) carbinol carbons.
Hoye TR, et al.
Nature Protocols, 2(10), 2451-2458 (2007)
Thomas R Hoye et al.
Organic letters, 12(8), 1768-1771 (2010-03-27)
The relative magnitudes of the chemical shift differences (Deltadeltas) in the two diastereomers of menthyl esters of known chiral derivatizing agents (CDAs) were compared to those of the alpha-methoxy-alpha-trifluoromethyl-1-naphthylacetyl (MTN((1))A) analogues I. Discrimination of the terminal diastereotopic methyl resonances in
Hiroshi Hasegawa et al.
Journal of mass spectrometry : JMS, 46(5), 502-507 (2011-04-19)
D-Serine is a co-agonist of the N-methyl-D-aspartate receptor in glutamate neurotransmission and has been proposed as a potential therapeutic agent for schizophrenia. However, D-serine also acts as a nephrotoxic substance in rats at high doses. To investigate the pharmacokinetics and
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