155268
(R)-(+)-α-甲氧基-α-三氟甲基苯乙酸
99%
别名:
(+)-MTPA, Mosher 酸
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关于此项目
线性分子式:
C6H5C(OCH3)(CF3)CO2H
化学文摘社编号:
分子量:
234.17
UNSPSC Code:
12352112
NACRES:
NA.22
PubChem Substance ID:
EC Number:
243-829-5
Beilstein/REAXYS Number:
3591560
MDL number:
Assay:
99%
Form:
solid
产品名称
(R)-(+)-α-甲氧基-α-三氟甲基苯乙酸, 99%
InChI key
JJYKJUXBWFATTE-SECBINFHSA-N
InChI
1S/C10H9F3O3/c1-16-9(8(14)15,10(11,12)13)7-5-3-2-4-6-7/h2-6H,1H3,(H,14,15)/t9-/m1/s1
SMILES string
CO[C@@](C(O)=O)(c1ccccc1)C(F)(F)F
assay
99%
form
solid
optical activity
[α]20/D +72°, c = 1.6 in methanol
optical purity
ee: 99% (GLC)
refractive index
n20/D 1.473 (lit.)
bp
105-107 °C/1 mmHg (lit.)
mp
46-49 °C (lit.)
density
1.344 g/mL at 25 °C (lit.)
functional group
carboxylic acid
ether
fluoro
phenyl
storage temp.
2-8°C
Quality Level
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Application
(R)-(+)-α-Methoxy-α-trifluoromethylphenylacetic acid is commonly used as a derivatizing agent in Mosher ester analysis, an NMR-based method for determining the absolute configuration of the chiral carbon center in a secondary alcohol.
Other Notes
doi:10.1038/nprot.2007.354
Packaging
Bottomless glass bottle. Contents are inside inserted fused cone.
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
235.4 °F - closed cup
flash_point_c
113 °C - closed cup
ppe
dust mask type N95 (US), Eyeshields, Gloves
Lidia De Luca et al.
The Journal of organic chemistry, 72(10), 3955-3957 (2007-04-11)
An effective route to chiral optically active 2-substituted benzofurans directly from carboxylic acids is reported. This procedure, which allows the preparation of alpha-alkyl-2-benzofuranmethanamines from N-protected alpha-amino acids without sensible racemization phenomena, proceeds in good yields under mild conditions with the
Tetrahedron Asymmetry, 18, 975-975 (2007)
Mosher ester analysis for the determination of absolute configuration of stereogenic (chiral) carbinol carbons.
Hoye TR, et al.
Nature Protocols, 2(10), 2451-2458 (2007)
D B Matthews et al.
Journal of chromatography. B, Biomedical sciences and applications, 695(2), 279-285 (1997-08-01)
Methods for the nuclear magnetic resonance and gas chromatographic analysis of the enantiomers of p-trifluoromethylmandelic acid (p-TFM) and Mosher's acid (alpha-methoxy-alpha-(trifluoromethyl)phenylacetic acid) present in rat urine samples are described. Gas chromartography was performed using cyclodextrin capillary columns with both compounds
J Martín Torres-Valencia et al.
Phytochemical analysis : PCA, 13(6), 329-332 (2002-12-24)
A method to determine the absolute configuration of 2,3-epoxy-2-methylbutanoate ester residues in natural products is presented, based on (i) the reduction of the ester function to yield a 2-methyl-1,2-butanediol, (ii) esterification of the obtained primary alcohol with either (R)-(+)- or
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