156124
氧尼酸 钾盐
97%
别名:
4,6-二羟基-1,3,5-三嗪-2-羧酸 钾盐, 尿囊毒酸
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关于此项目
经验公式（希尔记法）:
C4H2KN3O4
化学文摘社编号:
分子量:
195.17
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352100
EC Number:
218-627-5
MDL number:
Assay:
97%
Quality Level
assay
97%
mp
300 °C (lit.)
SMILES string
[K+].[O-]C(=O)C1=NC(=O)NC(=O)N1
InChI
1S/C4H3N3O4.K/c8-2(9)1-5-3(10)7-4(11)6-1;/h(H,8,9)(H2,5,6,7,10,11);/q;+1/p-1
InChI key
IAPCTXZQXAVYNG-UHFFFAOYSA-M
Application
氧嗪酸钾盐是尿酸酶的抑制剂。sigma 公司的产品已用在大鼠中抑制 5-氟尿嘧啶诱导的胃肠道毒性，而不损失其抗肿瘤活性。它也被用于诱导大鼠高尿酸血症；因为它抑制尿酸代谢。
存储类别
11 - Combustible Solids
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
T Shirasaka et al.
Cancer research, 53(17), 4004-4009 (1993-09-01)
The possibility of decreasing the gastrointestinal (GI) toxic effects of 5-fluorouracil (5-FU) on the digestive tract such as its injury of cells and induction of diarrhea, without reducing its antitumor activity, was investigated in rats. Oxonic acid was found to
Kei Nishizawa et al.
PloS one, 14(4), e0214862-e0214862 (2019-04-06)
The effects of hyperuricemia on the expression of kidney drug transporters and on the pharmacokinetics of several substrate drugs were examined. We first established a rat model of hyperuricemia without marked symptoms of chronic kidney failure by 10-day co-administration of
Haruka Fujikawa et al.
Antioxidants (Basel, Switzerland), 9(5) (2020-05-10)
The oxidant/antioxidant imbalance plays a pivotal role in the lung. Uric acid (UA), an endogenous antioxidant, is highly present in lung tissue, however, its impact on lung function under pathophysiological conditions remains unknown. In this work, pharmacological and genetic inhibition
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| 156124-5G | 04061835554294 |
| 156124-25G | 04061833416624 |
| 156124-100G | 04061838742469 |