156124
氧尼酸 钾盐
97%
别名:
4,6-二羟基-1,3,5-三嗪-2-羧酸 钾盐, 尿囊毒酸
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关于此项目
经验公式（希尔记法）:
C4H2KN3O4
化学文摘社编号:
分子量:
195.17
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352100
EC Number:
218-627-5
MDL number:
产品名称
氧尼酸 钾盐, 97%
InChI key
IAPCTXZQXAVYNG-UHFFFAOYSA-M
InChI
1S/C4H3N3O4.K/c8-2(9)1-5-3(10)7-4(11)6-1;/h(H,8,9)(H2,5,6,7,10,11);/q;+1/p-1
SMILES string
[K+].[O-]C(=O)C1=NC(=O)NC(=O)N1
assay
97%
mp
300 °C (lit.)
Quality Level
Application
氧嗪酸钾盐是尿酸酶的抑制剂。sigma 公司的产品已用在大鼠中抑制 5-氟尿嘧啶诱导的胃肠道毒性，而不损失其抗肿瘤活性。它也被用于诱导大鼠高尿酸血症；因为它抑制尿酸代谢。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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PloS one, 14(4), e0214862-e0214862 (2019-04-06)
The effects of hyperuricemia on the expression of kidney drug transporters and on the pharmacokinetics of several substrate drugs were examined. We first established a rat model of hyperuricemia without marked symptoms of chronic kidney failure by 10-day co-administration of
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The Journal of pharmacy and pharmacology, 70(1), 124-132 (2017-10-24)
Traditional Chinese herbal formulas are difficult to be understood because of complex compositions and specific therapeutic principles. To better understand herbal compatibility in Traditional Chinese medicine (TCM), this study was conducted to investigate the effects of a Chinese pharmacopoeia-listed formula
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The oxidant/antioxidant imbalance plays a pivotal role in the lung. Uric acid (UA), an endogenous antioxidant, is highly present in lung tissue, however, its impact on lung function under pathophysiological conditions remains unknown. In this work, pharmacological and genetic inhibition
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Potential underlying molecular mechanisms for uric acid-induced lipid metabolic disturbances had not been elucidated clearly. This study investigated the effects and underlying mechanisms of uric acid on the development of lipid metabolic disorders. We collected blood samples from 100 healthy
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