156361
海因
98%
别名:
2,4-咪唑啉二酮, 海因
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关于此项目
经验公式（希尔记法）:
C3H4N2O2
化学文摘社编号:
分子量:
100.08
UNSPSC Code:
12352100
NACRES:
NA.22
PubChem Substance ID:
EC Number:
207-313-3
Beilstein/REAXYS Number:
110598
MDL number:
Assay:
98%
Form:
powder
产品名称
海因, 98%
InChI key
WJRBRSLFGCUECM-UHFFFAOYSA-N
InChI
1S/C3H4N2O2/c6-2-1-4-3(7)5-2/h1H2,(H2,4,5,6,7)
SMILES string
O=C1CNC(=O)N1
assay
98%
form
powder
mp
218-220 °C (lit.)
Quality Level
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Application
本产品已被用作底物（在 40℃ 和 pH 9.0 下），以测定红小豆提取物中的 D -海因酶活性。
用于合成以下物质的反应物：
抗癌药物 N-苄基无赖氨酸视蛋白类似物
D-谷氨酸基抑制剂
抗糖尿病铬-2,4-噻唑烷二酮类
具有脑渗透性的GSK-3β抑制剂
作为 15-PGDH 抑制剂的噻唑烷二酮衍生物
放射增敏剂
抗癌药物 N-苄基无赖氨酸视蛋白类似物
D-谷氨酸基抑制剂
抗糖尿病铬-2,4-噻唑烷二酮类
具有脑渗透性的GSK-3β抑制剂
作为 15-PGDH 抑制剂的噻唑烷二酮衍生物
放射增敏剂
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Effect of treatment with compressed CO2 and propane on D-hydantoinase activity
Andrade JM, et al.
Journal of Supercritical Fluids, 46(2), 342-350 (2008)
June Izquierdo et al.
Chemistry (Weinheim an der Bergstrasse, Germany), 25(53), 12431-12438 (2019-07-19)
A bifunctional amine/squaramide catalyst promoted direct aldol addition of an hydantoin surrogate to pyridine 2-carbaldehyde N-oxides to afford adducts bearing two vicinal tertiary/quaternary carbons in high diastereo- and enantioselectivity (d.r. up to >20:1; ee up to 98 %) is reported. Acid
Y Thirupathi Reddy et al.
Bioorganic & medicinal chemistry letters, 20(2), 600-602 (2009-12-17)
A series of (Z)-5-((N-benzyl-1H-indol-3-yl)methylene)imidazolidine-2,4-dione (9a-9m) and 5-((N-benzyl-1H-indol-3-yl)methylene)pyrimidine-2,4,6(1H,3H,5H)-trione (10a-10i) derivatives that incorporate a variety of aromatic substituents in both the indole and N-benzyl moieties have been synthesized. These analogs were evaluated for their radiosensitization activity against the HT-29 cell line. Three
Meltem Ceylan-Ünlüsoy et al.
Journal of enzyme inhibition and medicinal chemistry, 25(6), 784-789 (2010-08-07)
A series of chromonyl-2,4-thiazolidinediones/imidazolidinediones/2-thioxo-imidazolidine-4-ones (IIIa-i, IVa-i) was prepared by Knoevenagel reaction of 2,4-thiazolidinedione/2,4-imidazolidinedione/2-thioxo-imidazolidine-4-one (IIa-c) with 2/3-formyl chromone (Ia-b) and then alkylation with methyl/ethyl iodide. The prepared compounds were tested for their insulinotropic activities in INS-1 cells. Compounds ıVb and ıVc
Lixuan Zhan et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 33(1), 1313-1329 (2018-08-28)
Hypoxic preconditioning (HPC) alleviates the selective and delayed neuronal death in the hippocampal CA1 region induced by transient global cerebral ischemia (tGCI). This type of cell death may include different programmed cell death mechanisms, namely, apoptosis and necroptosis. Although apoptotic
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