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文件

156361

海因

Name: 海因
Brand: ALDRICH

98%

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别名:

2,4-咪唑啉二酮, 海因

经验公式（希尔记法）:

C₃H₄N₂O₂

CAS号:

461-72-3

分子量:

100.08

Beilstein:

110598

EC 号:

207-313-3

MDL编号:

MFCD00005259

PubChem化学物质编号:

24849609

NACRES:

NA.22

检测方案

98%

形式

powder

mp

218-220 °C (lit.)

SMILES string

O=C1CNC(=O)N1

InChI

1S/C3H4N2O2/c6-2-1-4-3(7)5-2/h1H2,(H2,4,5,6,7)

InChI key

WJRBRSLFGCUECM-UHFFFAOYSA-N

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应用

本产品已被用作底物（在 40℃ 和 pH 9.0 下），以测定红小豆提取物中的 D -海因酶活性。

用于合成以下物质的反应物：
抗癌药物 N-苄基无赖氨酸视蛋白类似物
D-谷氨酸基抑制剂
抗糖尿病铬-2,4-噻唑烷二酮类
具有脑渗透性的GSK-3β抑制剂
作为 15-PGDH 抑制剂的噻唑烷二酮衍生物
放射增敏剂

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

分析证书(COA)

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示例

T1503

货号

25G

包装规格/数量

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705578-5MG-PW

PL860-CGA/SHF-1EA

MMYOMAG-74K-13

1000309185

输入内容 1.000309185)

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Novel substituted (Z)-5-((N-benzyl-1H-indol-3-yl)methylene)imidazolidine-2,4-diones and 5-((N-benzyl-1H-indol-3-yl)methylene)pyrimidine-2,4,6(1H,3H,5H)-triones as potent radio-sensitizing agents.

Y Thirupathi Reddy et al.

Bioorganic & medicinal chemistry letters, 20(2), 600-602 (2009-12-17)

A series of (Z)-5-((N-benzyl-1H-indol-3-yl)methylene)imidazolidine-2,4-dione (9a-9m) and 5-((N-benzyl-1H-indol-3-yl)methylene)pyrimidine-2,4,6(1H,3H,5H)-trione (10a-10i) derivatives that incorporate a variety of aromatic substituents in both the indole and N-benzyl moieties have been synthesized. These analogs were evaluated for their radiosensitization activity against the HT-29 cell line. Three

Asymmetric Synthesis of Adjacent Tri- and Tetrasubstituted Carbon Stereocenters: Organocatalytic Aldol Reaction of an Hydantoin Surrogate with Azaarene 2-Carbaldehydes.

June Izquierdo et al.

Chemistry (Weinheim an der Bergstrasse, Germany), 25(53), 12431-12438 (2019-07-19)

A bifunctional amine/squaramide catalyst promoted direct aldol addition of an hydantoin surrogate to pyridine 2-carbaldehyde N-oxides to afford adducts bearing two vicinal tertiary/quaternary carbons in high diastereo- and enantioselectivity (d.r. up to >20:1; ee up to 98 %) is reported. Acid

Effect of treatment with compressed CO₂ and propane on D-hydantoinase activity

Andrade JM, et al.

Journal of Supercritical Fluids, 46(2), 342-350 (2008)

Skincare products containing low concentrations of formaldehyde detected by the chromotropic acid method cannot be safely used in formaldehyde-allergic patients.

I Hauksson et al.

The British journal of dermatology, 174(2), 371-379 (2015-10-20)

Formaldehyde is a well-known contact sensitizer. Formaldehyde releasers are widely used preservatives in skincare products. It has been found that formaldehyde at concentrations allowed by the European Cosmetics Directive can cause allergic contact dermatitis. However, we still lack information on

Hypoxic preconditioning attenuates necroptotic neuronal death induced by global cerebral ischemia via Drp1-dependent signaling pathway mediated by CaMKIIα inactivation in adult rats.

Lixuan Zhan et al.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 33(1), 1313-1329 (2018-08-28)

Hypoxic preconditioning (HPC) alleviates the selective and delayed neuronal death in the hippocampal CA1 region induced by transient global cerebral ischemia (tGCI). This type of cell death may include different programmed cell death mechanisms, namely, apoptosis and necroptosis. Although apoptotic

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海因

98%

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