157201
金硫丁二钠 水合物
别名:
(1,2-Dicarboxyethylthio)gold 二钠盐 水合物, 巯基丁二酸金（I） 二钠盐, 金硫苹果酸钠 水合物
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关于此项目
线性分子式:
NaO2CCH2CH(SAu)CO2Na · xH2O
分子量:
390.08 (anhydrous basis)
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352100
MDL number:
InChI
1S/C4H6O4S.Au.2Na.H2O/c5-3(6)1-2(9)4(7)8;;;;/h2,9H,1H2,(H,5,6)(H,7,8);;;;1H2/q;3*+1;/p-3
SMILES string
O.[Na+].[Na+].[O-]C(=O)CC(S[Au])C([O-])=O
InChI key
YLQOAPBVYJCTPW-UHFFFAOYSA-K
form
powder
Quality Level
Application
金硫代苹果酸钠水合物用于高迁移率族盒染色体蛋白1（HMGB1）蛋白质印迹。
General description
金硫代苹果酸钠具有抗风湿特性，并表现出对结核分枝杆菌的抑制作用。
Cecilia K Zetterström et al.
Journal of leukocyte biology, 83(1), 31-38 (2007-10-05)
Gold compounds such as gold sodium thiomalate (GST) can reduce the symptoms of rheumatoid arthritis (RA), although their mechanism of action is not well defined. As the proinflammatory mediator high mobility group box chromosomal protein 1 (HMGB1) may play a
Kathryn E A Lougheed et al.
Tuberculosis (Edinburgh, Scotland), 89(5), 364-370 (2009-08-25)
Mycobacterium tuberculosis has an on-going impact on global public health and new therapeutics to treat tuberculosis are urgently required. The emergence of drug resistant tuberculosis poses a serious threat to the control of this pathogen, and the development of drugs
Christoph Tabeling et al.
Journal of vascular research, 52(4), 279-288 (2016-02-20)
Pulmonary vascular hyperresponsiveness is a main characteristic of pulmonary arterial hypertension (PAH). In PAH patients, elevated levels of the vasoconstrictors thromboxane A2 (TXA2), endothelin (ET)-1 and serotonin further contribute to pulmonary hypertension. Protein kinase C (PKC) isozyme alpha (PKCα) is
Meghan Riddell et al.
Nature communications, 9(1), 5357-5357 (2018-12-19)
Strict regulation of proliferation is vital for development, whereas unregulated cell proliferation is a fundamental characteristic of cancer. The polarity protein atypical protein kinase C lambda/iota (aPKCλ) is associated with cell proliferation through unknown mechanisms. In endothelial cells, suppression of
Farivash Darabi et al.
Journal of inorganic biochemistry, 149, 102-107 (2015-04-14)
Aurothiomalate (AuTm) is an old, clinically established, antiarthritic gold drug that is currently being reconsidered as a candidate drug for cancer treatment and for other therapeutic indications within a more general drug repositioning program. As the biological effects of gold
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