158194
2,2′-二硫双(5-硝基吡啶)
96%
别名:
DTNP, 双(5-硝基-2-吡啶基)二硫化物
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关于此项目
经验公式（希尔记法）:
C10H6N4O4S2
化学文摘社编号:
分子量:
310.31
Beilstein:
305413
EC 号:
MDL编号:
UNSPSC代码:
12352100
PubChem化学物质编号:
NACRES:
NA.22
质量水平
方案
96%
表单
solid
mp
155-157 °C (lit.)
官能团
disulfide
nitro
SMILES字符串
[O-][N+](=O)c1ccc(SSc2ccc(cn2)[N+]([O-])=O)nc1
InChI
1S/C10H6N4O4S2/c15-13(16)7-1-3-9(11-5-7)19-20-10-4-2-8(6-12-10)14(17)18/h1-6H
InChI key
ROUFCTKIILEETD-UHFFFAOYSA-N
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一般描述
2,2'-二硫代双（5-硝基吡啶）是芳香族二硫化物。
应用
使用 2,2'-二硫代双（5-硝基吡啶）：
- 用半胱氨酸活化试剂研究 G 蛋白偶联受体的核磁共振波谱
- 在用于受保护的含硒代半胱氨酸的肽的去保护测定中
- 对半胱氨酸和硒代半胱氨酸侧链上的 p -甲氧基苄基和乙酰胺甲基进行脱保护
- 从半胱氨酸和硒代半胱氨酸侧链中去除 p -甲氧基苄基保护基
警示用语：
Warning
危险声明
危险分类
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
P Sharma et al.
Analytical biochemistry, 189(2), 173-177 (1990-09-01)
A sensitive and simple method is described for the quantitative determination of free sulfhydryl (-SH) groups on polymer supports. The method includes the reaction of 4,4'-dimethoxytrityloxy-S-(2-thio-5-nitropyridyl)-2-mercapto ethane (DTNPME) with polymer-supported sulfhydryl groups. After removal of excess reagent through washing, a
Alayne L Schroll et al.
Journal of peptide science : an official publication of the European Peptide Society, 18(1), 1-9 (2011-11-16)
Of all the commercially available amino acid derivatives for solid phase peptide synthesis, none has a greater abundance of side-chain protection diversity than cysteine. The high reactivity of the cysteine thiol necessitates its attenuation during peptide construction. Moreover, the propensity
Leah S Cohen et al.
Biopolymers, 102(1), 16-29 (2013-07-31)
Structural analysis by NMR of G protein-coupled receptors (GPCRs) has proven to be extremely challenging. To reduce the number of peaks in the NMR spectra by segmentally labeling a GPCR, we have developed a Guided Reconstitution method that includes the
M K Park et al.
Experimental physiology, 80(5), 835-842 (1995-09-01)
Ca(2+)-activated K+ currents (IK(Ca)) and voltage-dependent Ca(2+)-insensitive K+ currents (IK(V)) were recorded using the patch clamp technique to study the pulmonary (PASMC) and ear arterial smooth muscle cells (EASMC) of the rabbit and the possible regulatory mechanisms related to hypoxia.
Uncoupling and energy transfer inhibition of photophosphorylation by sulfhydryl reagents.
J V Moroney et al.
The Journal of biological chemistry, 255(14), 6670-6674 (1980-07-25)
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