158194
2,2′-二硫双(5-硝基吡啶)
96%
别名:
DTNP, 双(5-硝基-2-吡啶基)二硫化物
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关于此项目
经验公式（希尔记法）:
C10H6N4O4S2
化学文摘社编号:
分子量:
310.31
Beilstein:
305413
EC 号:
MDL编号:
UNSPSC代码:
12352100
PubChem化学物质编号:
NACRES:
NA.22
质量水平
方案
96%
表单
solid
mp
155-157 °C (lit.)
官能团
disulfide
nitro
SMILES字符串
[O-][N+](=O)c1ccc(SSc2ccc(cn2)[N+]([O-])=O)nc1
InChI
1S/C10H6N4O4S2/c15-13(16)7-1-3-9(11-5-7)19-20-10-4-2-8(6-12-10)14(17)18/h1-6H
InChI key
ROUFCTKIILEETD-UHFFFAOYSA-N
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一般描述
2,2'-二硫代双（5-硝基吡啶）是芳香族二硫化物。
应用
使用 2,2'-二硫代双（5-硝基吡啶）：
- 用半胱氨酸活化试剂研究 G 蛋白偶联受体的核磁共振波谱
- 在用于受保护的含硒代半胱氨酸的肽的去保护测定中
- 对半胱氨酸和硒代半胱氨酸侧链上的 p -甲氧基苄基和乙酰胺甲基进行脱保护
- 从半胱氨酸和硒代半胱氨酸侧链中去除 p -甲氧基苄基保护基
警示用语：
Warning
危险声明
危险分类
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
Leah S Cohen et al.
Biopolymers, 102(1), 16-29 (2013-07-31)
Structural analysis by NMR of G protein-coupled receptors (GPCRs) has proven to be extremely challenging. To reduce the number of peaks in the NMR spectra by segmentally labeling a GPCR, we have developed a Guided Reconstitution method that includes the
G J Stephens et al.
Pflugers Archiv : European journal of physiology, 431(3), 435-442 (1996-01-01)
The effects of cysteine-modifying reagents on the gating of rat cloned Kv1.4 channels expressed in HEK-293 cells were examined using the whole-cell patch-clamp technique. Cells transfected with Kv1.4 expressed a rapidly inactivating K+ current with a mid-point of activation of
A Li et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 18(17), 6740-6747 (1998-08-26)
Functional modifications of neuronal P/Q-type voltage-dependent Ca2+ channels expressed in Xenopus oocytes by oxidation were examined electrophysiologically. Oxidation by external H2O2 enhanced the whole-oocyte currents through the Ca2+ channels composed of the alpha1A, alpha2/delta, and beta3 subunits at negative voltages
Alayne L Schroll et al.
Journal of peptide science : an official publication of the European Peptide Society, 18(1), 1-9 (2011-11-16)
Of all the commercially available amino acid derivatives for solid phase peptide synthesis, none has a greater abundance of side-chain protection diversity than cysteine. The high reactivity of the cysteine thiol necessitates its attenuation during peptide construction. Moreover, the propensity
P Sharma et al.
Analytical biochemistry, 189(2), 173-177 (1990-09-01)
A sensitive and simple method is described for the quantitative determination of free sulfhydryl (-SH) groups on polymer supports. The method includes the reaction of 4,4'-dimethoxytrityloxy-S-(2-thio-5-nitropyridyl)-2-mercapto ethane (DTNPME) with polymer-supported sulfhydryl groups. After removal of excess reagent through washing, a
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