160393
磷酸伯安喹
98%
别名:
8-(4-氨基-1-甲基丁氨基)-6-甲氧基喹啉 二磷酸盐, 伯氨喹 二磷酸盐
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关于此项目
经验公式（希尔记法）:
C15H21N3O · 2H3PO4
化学文摘社编号:
分子量:
455.34
UNSPSC Code:
12352100
NACRES:
NA.22
PubChem Substance ID:
EC Number:
200-560-8
Beilstein/REAXYS Number:
3812133
MDL number:
Assay:
98%
Form:
powder
form
powder
InChI key
GJOHLWZHWQUKAU-UHFFFAOYSA-N
InChI
1S/C15H21N3O.2H3O4P/c1-11(5-3-7-16)18-14-10-13(19-2)9-12-6-4-8-17-15(12)14;2*1-5(2,3)4/h4,6,8-11,18H,3,5,7,16H2,1-2H3;2*(H3,1,2,3,4)
SMILES string
OP(O)(O)=O.OP(O)(O)=O.COc1cc(NC(C)CCCN)c2ncccc2c1
assay
98%
mp
205-206 °C (dec.) (lit.)
solubility
water: soluble 50 mg/mL, clear, orange to red
functional group
amine, phosphate
Quality Level
Application
伯喹二磷酸在基于比色微孔板的室温检测中被用于确定细胞培养中的尿素合成。它还被用于制备伯氨喹，一种已确定的抗肿瘤药物。
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Oral - Muta. 2 - Repr. 2
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
N P Dhammika Nanayakkara et al.
Antimicrobial agents and chemotherapy, 52(6), 2130-2137 (2008-04-02)
8-Aminoquinolines are an important class of antiparasitic agents, with broad utility and excellent efficacy, but also limitations due to hematological toxicities, primarily methemoglobinemia and hemolysis. One representative from this class, (+/-)-8-[(4-amino-1-methylbutyl)amino]-6-methoxy-4-methyl-5-[3,4-dichlorophenoxy]quinoline succinate (NPC1161C), proved extremely efficacious in animal models of
Robert J X Zawada et al.
Biochemistry and cell biology = Biochimie et biologie cellulaire, 87(3), 541-544 (2009-05-19)
Urea is the major nitrogenous end product of protein metabolism in mammals. Here, we describe a quantitative, sensitive method for urea determination using a modified Jung reagent. This assay is specific for urea and is unaffected by ammonia, a common
Nicholas J White
The Lancet. Infectious diseases, 13(2), 175-181 (2012-11-28)
Falciparum malaria is transmitted by anopheline mosquitoes that have fed on blood containing gametocytes of Plasmodium falciparum. In areas of low malaria transmission, where symptomatic infections contribute substantially to malaria transmission, the use of gametocytocidal drugs reduces the incidence of
Issahy Cano et al.
Frontiers in cell and developmental biology, 9, 734346-734346 (2021-10-08)
Galectin-3 (Gal3) is a carbohydrate-binding protein reported to promote angiogenesis by influencing vascular endothelial growth factor-A receptor 2 (VEGFR2) signal transduction. Here we evaluated whether the ability of Gal3 to function as an angiogenic factor involved vascular endothelial growth factor
Stefan Hoyer et al.
PloS one, 7(10), e45797-e45797 (2012-10-11)
Recent studies have shown that Plasmodium falciparum malaria parasites in Pailin province, along the border between Thailand and Cambodia, have become resistant to artemisinin derivatives. To better define the epidemiology of P. falciparum populations and to assess the risk of
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