161497
3,4-(亚甲二氧基)苯胺
97%
别名:
胡椒胺
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关于此项目
经验公式(希尔记法):
C7H7NO2
化学文摘社编号:
分子量:
137.14
Beilstein:
4919
EC 号:
MDL编号:
UNSPSC代码:
12352100
PubChem化学物质编号:
NACRES:
NA.22
方案
97%
沸点
144 °C/16 mmHg (lit.)
mp
39-41 °C (lit.)
SMILES字符串
Nc1ccc2OCOc2c1
InChI
1S/C7H7NO2/c8-5-1-2-6-7(3-5)10-4-9-6/h1-3H,4,8H2
InChI key
XGNXYCFREOZBOL-UHFFFAOYSA-N
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一般描述
3,4-(亚甲基二氧基)苯胺是药学上重要的苯胺衍生物。在 Shvo 催化剂的存在下,它与环状仲烷基胺进行 N-烷基化反应,生成 N-芳基吡咯烷。
应用
3,4-(亚甲基二氧基)苯胺用于合成 γ-谷氨酰苯胺。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
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A Rsoswsky et al.
Journal of medicinal chemistry, 22(9), 1034-1037 (1979-09-01)
Nine heretofore unknown mono- and dihydroxyanilide analogues of the cytotoxic mushroom metabolites L-glutamic acid gamma-(4-hydroxyanilide) (1) and L-glutamic acid gamma-(3,4-dihydroxyanilide) (3, agaridoxin) were synthesized and tested as inhibitors of the growth of B16 mouse melanoma cells in culture. The naturally
K N Vennila et al.
Bioorganic chemistry, 81, 184-190 (2018-08-24)
The induced fit docking of anilino quinoline scaffold results in the required hydrogen bonding interactions with amino acid residues in the orthosteric site of 3 Phosphoinositide dependent kinase (PDK1). The rational design of 4-substituted amino quinolines is carried out and
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