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163201

N,N′-二环己基-4-吗啉脒

Name: <I>N,N′</I>-二环己基-4-吗啉脒
Brand: ALDRICH

98%

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关于此项目

经验公式（希尔记法）:

C₁₇H₃₁N₃O

化学文摘社编号:

4975-73-9

分子量:

293.45

NACRES:

NA.22

PubChem Substance ID:

24850028

UNSPSC Code:

12352100

EC Number:

225-622-1

MDL number:

MFCD00063252

Assay:

98%

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属性

Quality Level

100

assay

98%

mp

105-107 °C (lit.)

functional group

amine, ether

SMILES string

C1CCC(CC1)N\C(=N\C2CCCCC2)N3CCOCC3

InChI

1S/C17H31N3O/c1-3-7-15(8-4-1)18-17(20-11-13-21-14-12-20)19-16-9-5-2-6-10-16/h15-16H,1-14H2,(H,18,19)

InChI key

OZNYZQOTXQSUJM-UHFFFAOYSA-N

说明

General description

N,N′-Dicyclohexyl-4-morpholinecarboxamidine is kidney-selective ATP-sensitive potassium blocker. It is an an orally effective nonkaliuretic diuretic in rats.

Application

N,N′-Dicyclohexyl-4-morpholinecarboxamidine was used as reagent in the synthesis of alkoxyalkyl analogs of nucleotide phosphonates, cidofovir and cyclic cidofovir.

pictograms

GHS07

signalword

Warning

hcodes

H315,H319,H335

pcodes

P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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An ATP-sensitive potassium channel blocker suppresses sodium-induced hypertension through increased secretion of urinary kallikrein.

Yuji Kamata et al.

Hypertension research : official journal of the Japanese Society of Hypertension, 32(3), 220-226 (2009-03-06)

It is suggested that an ATP-sensitive potassium channel blocker suppresses sodium-induced hypertension through increased secretion of urinary kallikrein. We reported that glibenclamide, an ATP-sensitive potassium channel blocker, accelerated dose-dependent secretion of renal kallikrein in sliced kidney cortex and in vivo

Synthesis and diuretic activity of alkyl- and arylguanidine analogs of N,N'-dicyclohexyl-4-morpholinecarboxamidine in rats and dogs.

S C Perricone et al.

Journal of medicinal chemistry, 37(22), 3693-3700 (1994-10-28)

Random screening identified N,N'-dicyclohexyl-4-morpholinecarboxamidine (U-18177, 1) as an orally effective nonkaliuretic diuretic in rats. The diuretic profile of 1 and its 1-adamantyl analog (U-37883A, 4) was confirmed orally in dogs, when they were less potent than standard diuretics but showed

Enhanced inhibition of orthopoxvirus replication in vitro by alkoxyalkyl esters of cidofovir and cyclic cidofovir.

Earl R Kern et al.

Antimicrobial agents and chemotherapy, 46(4), 991-995 (2002-03-19)

The nucleotide phosphonates cidofovir (CDV) and cyclic cidofovir (cCDV) are potent antiviral compounds when administered parenterally but are not well absorbed orally. These compounds have been reported to have activity against orthopoxvirus replication in vitro and in animal models when

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货号	GTIN
163201-25G	04061833397923