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文件

163201

N,N′-二环己基-4-吗啉脒

Name: <I>N,N′</I>-二环己基-4-吗啉脒
Brand: ALDRICH

98%

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经验公式（希尔记法）:

C₁₇H₃₁N₃O

CAS号:

4975-73-9

分子量:

293.45

EC 号:

225-622-1

MDL编号:

MFCD00063252

PubChem化学物质编号:

24850028

NACRES:

NA.22

质量水平

100

检测方案

98%

mp

105-107 °C (lit.)

SMILES string

C1CCC(CC1)N\C(=N\C2CCCCC2)N3CCOCC3

InChI

1S/C17H31N3O/c1-3-7-15(8-4-1)18-17(20-11-13-21-14-12-20)19-16-9-5-2-6-10-16/h15-16H,1-14H2,(H,18,19)

InChI key

OZNYZQOTXQSUJM-UHFFFAOYSA-N

一般描述

N,N′-Dicyclohexyl-4-morpholinecarboxamidine is kidney-selective ATP-sensitive potassium blocker. It is an an orally effective nonkaliuretic diuretic in rats.

应用

N,N′-Dicyclohexyl-4-morpholinecarboxamidine was used as reagent in the synthesis of alkoxyalkyl analogs of nucleotide phosphonates, cidofovir and cyclic cidofovir.

象形图

GHS07

警示用语：

Warning

危险声明

H315 - H319 - H335

预防措施声明

P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338

危险分类

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

靶器官

Respiratory system

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

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示例

T1503

货号

25G

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An ATP-sensitive potassium channel blocker suppresses sodium-induced hypertension through increased secretion of urinary kallikrein.

Yuji Kamata et al.

Hypertension research : official journal of the Japanese Society of Hypertension, 32(3), 220-226 (2009-03-06)

It is suggested that an ATP-sensitive potassium channel blocker suppresses sodium-induced hypertension through increased secretion of urinary kallikrein. We reported that glibenclamide, an ATP-sensitive potassium channel blocker, accelerated dose-dependent secretion of renal kallikrein in sliced kidney cortex and in vivo

Enhanced inhibition of orthopoxvirus replication in vitro by alkoxyalkyl esters of cidofovir and cyclic cidofovir.

Earl R Kern et al.

Antimicrobial agents and chemotherapy, 46(4), 991-995 (2002-03-19)

The nucleotide phosphonates cidofovir (CDV) and cyclic cidofovir (cCDV) are potent antiviral compounds when administered parenterally but are not well absorbed orally. These compounds have been reported to have activity against orthopoxvirus replication in vitro and in animal models when

Synthesis and diuretic activity of alkyl- and arylguanidine analogs of N,N'-dicyclohexyl-4-morpholinecarboxamidine in rats and dogs.

S C Perricone et al.

Journal of medicinal chemistry, 37(22), 3693-3700 (1994-10-28)

Random screening identified N,N'-dicyclohexyl-4-morpholinecarboxamidine (U-18177, 1) as an orally effective nonkaliuretic diuretic in rats. The diuretic profile of 1 and its 1-adamantyl analog (U-37883A, 4) was confirmed orally in dogs, when they were less potent than standard diuretics but showed

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