163651
硫代乙酰苯胺
98%
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关于此项目
线性分子式:
CH3CSNHC6H5
化学文摘社编号:
分子量:
151.23
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352100
EC Number:
211-288-4
MDL number:
Assay:
98%
Form:
powder
InChI key
MWCGLTCRJJFXKR-UHFFFAOYSA-N
InChI
1S/C8H9NS/c1-7(10)9-8-5-3-2-4-6-8/h2-6H,1H3,(H,9,10)
SMILES string
CC(=S)Nc1ccccc1
assay
98%
form
powder
mp
76-79 °C (lit.)
functional group
amine
General description
Metabolism and acute toxicity of thioacetanilide has been studied in rat. Thioacetanilide undergoes nucleophilic addition reaction with superoxide ion in dimethyl sulfoxide.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
法规信息
新产品
此项目有
Peng Zhan et al.
Bioorganic & medicinal chemistry, 17(16), 5775-5781 (2009-08-01)
A series of 2-(1-aryl-1H-imidazol-2-ylthio)acetamide [imidazole thioacetanilide (ITA)] derivatives were synthesized and evaluated as potent inhibitors of human immunodeficiency virus type-1 (HIV-1). Among them, the most potent HIV-1 inhibitors were 4a5 (EC(50)=0.18microM), and 4a2 (EC(50)=0.20microM), which were more effective than the
Anna Michta et al.
Acta crystallographica. Section C, Crystal structure communications, 64(Pt 8), o411-o413 (2008-08-07)
The title compound, C(8)H(9)NS, has four symmetry-independent molecules in the asymmetric unit. These molecules link into two independent infinite N-H...S hydrogen-bonded chains in the a-axis direction with graph-set notation C(2)(2)(8). The NH-CS group adopts a trans conformation and forms a
Ester Muraglia et al.
Bioorganic & medicinal chemistry letters, 16(10), 2748-2752 (2006-03-01)
A series of aryltetrazolylacetanilides was synthesized and evaluated as HIV-1 non-nucleoside reverse transcriptase inhibitors on wild-type virus and on the clinically relevant K103N mutant strain. Extensive SAR investigation led to potent compounds, with nanomolar activity on K103N, and orally bioavailable
Reactivity of superoxide ion with thioamides in dimethyl sulfoxide.
Paez OA, et al.
The Journal of Organic Chemistry, 53(10), 2166-2170 (1988)
Xiao Li et al.
Bioorganic & medicinal chemistry, 20(18), 5527-5536 (2012-08-14)
In continuation of our efforts toward the discovery of potent HIV-1 NNRTIs with novel structures, we have employed a scaffold hopping strategy to explore the chemically diversed space of bioactive compounds. The original arylazolylthioacetanilide platform was replaced with different imidazopyridinylthioacetanilide
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