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Merck
CN

166391

1-甲酰吡咯烷

97%

别名:

吡咯烷-1-羧醛

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关于此项目

经验公式(希尔记法):
C5H9NO
化学文摘社编号:
分子量:
99.13
UNSPSC Code:
12352100
NACRES:
NA.22
PubChem Substance ID:
EC Number:
223-175-7
Beilstein/REAXYS Number:
106540
MDL number:
Assay:
97%
Form:
liquid
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InChI key

AGRIQBHIKABLPJ-UHFFFAOYSA-N

InChI

1S/C5H9NO/c7-5-6-3-1-2-4-6/h5H,1-4H2

SMILES string

[H]C(=O)N1CCCC1

assay

97%

form

liquid

refractive index

n20/D 1.479 (lit.)

bp

92-94 °C/15 mmHg (lit.)

density

1.04 g/mL at 25 °C (lit.)

Quality Level

General description

1-Formylpyrrolidine is the monomer constituent of gas clathrate inhibitor.

Application

1-Formylpyrrolidine was used in the synthesis of 1-oxa-3,4-dimethyl-5-(1-pyrrolldino)-2,2-di(tert-butyl)silacyclopentane and 1-oxa-4-isopropyl-5-(1-pyrrolidino)-2,2-di(tert-butyl)silacyclopentane.

存储类别

10 - Combustible liquids

wgk

WGK 3

flash_point_f

203.0 °F - closed cup

flash_point_c

95 °C - closed cup

ppe

Eyeshields, Gloves


历史批次信息供参考:

分析证书(COA)

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Preparation and synthetic utility of oxasilacyclopentane acetals derived from siliranes.
Shaw JT and Woerpel KA.
Tetrahedron, 53(48), 16597-16606 (1997)
Y Tanaka et al.
Journal of medicinal chemistry, 37(13), 2071-2078 (1994-06-24)
New compounds were synthesized by structural modification of 1-[1-(4-phenylbutanoyl)-L-prolyl]-pyrrolidine (SUAM-1221, 1) or 1-[1-(benzyloxycarbonyl)-L-proly]prolinal (Z-Pro-prolinal,2) and were tested for in vitro inhibitory activities against purified prolyl endopeptidase (PEP) from canine brain. In a series of compounds which lack a formyl or
Marco Pallavicini et al.
Bioorganic & medicinal chemistry letters, 14(23), 5827-5830 (2004-10-27)
Homochiral E and Z isomers of N-methylprolinal O-isopropyloxime and (1-methyl-2-pyrrolidinyl)methoxyimines were synthesized as candidate bioisosteres of nicotine and its isoxazolic analogue ABT 418. Two of them, namely (S)-2-isopropylideneaminooxymethyl- and (Z)-(S)-2-ethylideneaminooxymethyl-1-methylpyrrolidine, proved to bind at alpha4beta2 nicotinic acetylcholine receptor with submicromolar
Computational studies of structure and dynamics of clathrate inhibitor monomers in solution.
Gomez G, et al.
Industrial & Engineering Chemistry Research, 46(1), 131-142 (2007)
M Nanri et al.
Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 89(6), 323-329 (1987-06-01)
Based on the results of a previous report that prolyl endopeptidase (PPCE) inhibitors facilitated the acquisition of active avoidance response and retarded the extinction of the response, further studies were made on the effect of PPCE inhibitors on learning and

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