177466
4-甲基环己胺，顺反异构体混合物
97%
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关于此项目
线性分子式:
CH3C6H10NH2
化学文摘社编号:
分子量:
113.20
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352100
EC Number:
228-673-8
MDL number:
Assay:
97%
Form:
liquid
产品名称
4-甲基环己胺，顺反异构体混合物, 97%
InChI key
KSMVBYPXNKCPAJ-UHFFFAOYSA-N
InChI
1S/C7H15N/c1-6-2-4-7(8)5-3-6/h6-7H,2-5,8H2,1H3
SMILES string
CC1CCC(N)CC1
assay
97%
form
liquid
refractive index
n20/D 1.4531 (lit.)
bp
151-154 °C (lit.)
density
0.855 g/mL at 25 °C (lit.)
Quality Level
General description
Trans-4-methylcyclohexylamine is a spermidine synthase inhibitor.
signalword
Danger
hcodes
Hazard Classifications
Flam. Liq. 3 - Skin Corr. 1B
存储类别
3 - Flammable liquids
wgk
WGK 3
flash_point_f
80.6 °F - closed cup
flash_point_c
27 °C - closed cup
ppe
Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter
法规信息
危险化学品
此项目有
Masaki Kobayashi et al.
Biological & pharmaceutical bulletin, 28(4), 569-573 (2005-04-02)
In rat tissues, a decrease in spermidine, accompanied by an increase in spermine was induced by the oral administration (once daily for either 1 week or 1 month) of trans-4-methylcyclohexylamine (4MCHA), a spermidine synthase inhibitor. This is similar to the
TachaZi Plym Forshell et al.
Cancer prevention research (Philadelphia, Pa.), 3(2), 140-147 (2010-01-28)
The oncogenic transcription factor c-Myc (Myc) is frequently overexpressed in human cancers. Myc is known to induce or repress a large set of genes involved in cell growth and proliferation, explaining the selection for mutations in cancer that deregulate Myc
Masatake Sano et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 845(1), 80-83 (2006-08-26)
An assay for spermidine synthase (SPDS) activity in rat liver has been developed using micellar electrokinetic chromatography (MEKC) with laser-induced fluorescence (LIF) detection to enable the discovery of SPDS inhibitors. The assay was established by estimating the amount of spermidine
Keijiro Samejima
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 126(8), 529-542 (2006-08-02)
This review describes my work in the field of polyamine research for the last 35 years. My research started with developing the improved synthesis of decarboxylated S-adenosylmethionine and then moved to the purification of spermidine synthase from rat prostate. I
Trans-4-methylcyclohexylamine, a potent new inhibitor of spermidine synthase.
A Shirahata et al.
Chemical & pharmaceutical bulletin, 36(8), 3220-3222 (1988-08-01)
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