177989
氯甲酸异丁酯
98%
别名:
IBCF, 氯甲酸异丁酯
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关于此项目
线性分子式:
ClCO2CH2CH(CH3)2
化学文摘社编号:
分子量:
136.58
UNSPSC Code:
12352100
NACRES:
NA.22
PubChem Substance ID:
EC Number:
208-840-1
Beilstein/REAXYS Number:
956590
MDL number:
Assay:
98%
Form:
liquid
InChI key
YOETUEMZNOLGDB-UHFFFAOYSA-N
InChI
1S/C5H9ClO2/c1-4(2)3-8-5(6)7/h4H,3H2,1-2H3
SMILES string
CC(C)COC(Cl)=O
vapor pressure
0.33 mmHg ( 20 °C)
assay
98%
form
liquid
refractive index
n20/D 1.407 (lit.)
bp
128.8 °C (lit.)
solubility
benzene: miscible, chloroform: miscible, diethyl ether: miscible
density
1.053 g/mL at 25 °C (lit.)
functional group
chloro
Quality Level
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General description
氯甲酸异丁酯可用作肽试剂。在寡核苷酸合成中，IBCF 阻断了脱氧核糖核苷的5′-羟基功能。它也可用作缩合剂。
Application
- 牛磺酸挥发性衍生物的制备及其在气相色谱测定尿液牛磺酸中的应用：展示了异丁基碳酸氯在制备牛磺酸挥发性衍生物以进行气相色谱分析中的用途，为临床生物化学提供了方法学方面的进步（Masuoka 等人，1989 年）。
- 抑制胸腺嘧啶合成酶的喹唑啉类抗叶酸药物：合成 N10-炔丙基-5,8-二脱氮叶酸的四种寡（L-γ-谷氨酰）缀合物及其酶抑制作用：本文研究了喹唑啉类抗叶酸药物的合成和生物活性，使用包括异丁基碳酸氯在内的技术，与药物化学和药物开发相关（Pawelczak 等人，1989 年）。
- 通过混合酸酐法将肽偶联到蛋白质载体：讨论了一种使用异丁基碳酸氯将肽偶联到蛋白质的新技术，该技术在生物偶联化学和疫苗开发中很有用（Samokhin & Filimonov，1985 年）。
- 叶酸类似物在 C9-N10 桥区发生改变。18.11-氧代同氨蝶呤及其相关化合物的合成和抗肿瘤评价：研究了异丁基碳酸氯在合成用于癌症研究的叶酸类似物中的作用，表明其在治疗化学中的重要性（Nair 等人，1981 年）。
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 2 Inhalation - Acute Tox. 4 Oral - Eye Dam. 1 - Flam. Liq. 3 - Skin Corr. 1B
存储类别
3 - Flammable liquids
wgk
WGK 2
flash_point_f
96.8 °F - closed cup
flash_point_c
36 °C - closed cup
ppe
Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter
法规信息
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