184047
(S)-(+)-亮氨醇
96%
别名:
(S)-2-氨基-4-甲基-1-戊醇, 2-氨基-4-甲基-1-戊醇, L-亮氨醇
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关于此项目
线性分子式:
(CH3)2CHCH2CH(NH2)CH2OH
化学文摘社编号:
分子量:
117.19
Beilstein:
1719240
EC 号:
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
方案
96%
旋光性
[α]20/D +4°, c = 9 in ethanol
光学纯度
ee: 99% (GLC)
反应适用性
reaction type: solution phase peptide synthesis
折射率
n20/D 1.4511 (lit.)
沸点
198-200 °C/768 mmHg (lit.)
密度
0.917 g/mL at 25 °C (lit.)
应用
peptide synthesis
SMILES字符串
CC(C)C[C@H](N)CO
InChI
1S/C6H15NO/c1-5(2)3-6(7)4-8/h5-6,8H,3-4,7H2,1-2H3/t6-/m0/s1
InChI key
VPSSPAXIFBTOHY-LURJTMIESA-N
应用
合成氨肽酶 N 和磷脂酶 A2 抑制剂的原料。
警示用语：
Warning
危险声明
危险分类
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
储存分类代码
10 - Combustible liquids
WGK
WGK 3
闪点(°F)
195.8 °F - closed cup
闪点(°C)
91 °C - closed cup
个人防护装备
Eyeshields, Gloves, type ABEK (EN14387) respirator filter
法规信息
新产品
此项目有
C Bennion et al.
Journal of medicinal chemistry, 35(16), 2939-2951 (1992-08-07)
A series of substrate analogue inhibitors of pancreatic phospholipase A2 has been designed and synthesized. The compounds were tested in a novel dual-screening system based on parallel assays with monomeric and micellar substrates. Intermolecular nuclear Overhauser effects between vinylic protons
Chiral derivatives of xanthones and benzophenones: Synthesis, enantioseparation, molecular docking, and tumor cell growth inhibition studies.
Ye' Zaw Phyo et al.
Chirality, 33(4), 153-166 (2021-01-16)
Suraj Adhikari et al.
Chirality, 28(12), 789-794 (2016-11-30)
A convenient method using a fluorogenic agent, 4-chloro-7-nitro-1,2,3-benzoxadiazole (NBD-Cl), was developed for enantiomer separation of chiral aliphatic amines including amino alcohols by normal high-performance liquid chromatography. The enantiomer separation of chiral aliphatic amines as NBD derivatives was performed on six
Kevin X Chen et al.
Journal of medicinal chemistry, 52(5), 1370-1379 (2009-02-07)
The hepatitis C virus (HCV) infection is a leading cause of chronic liver disease. The moderate efficacy along with side effects of the current pegylated interferon and ribavirin combination therapy underscores the need for more effective and safer new treatment.
M C Fournié-Zaluski et al.
Journal of medicinal chemistry, 35(7), 1259-1266 (1992-04-03)
Derivatives of amino acids bearing various zinc-coordinating moieties (SH, COOH, CONHOH, and PO3H2) were synthesized and tested for their ability to inhibit aminopeptidase N (APN). Among them, beta-amino thiols were found to be the most efficient with IC50's in the
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