184047
(S)-(+)-亮氨醇
96%
别名:
(S)-2-氨基-4-甲基-1-戊醇, 2-氨基-4-甲基-1-戊醇, L-亮氨醇
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关于此项目
线性分子式:
(CH3)2CHCH2CH(NH2)CH2OH
化学文摘社编号:
分子量:
117.19
EC Number:
231-400-5
UNSPSC Code:
12352200
PubChem Substance ID:
Beilstein/REAXYS Number:
1719240
MDL number:
InChI key
VPSSPAXIFBTOHY-LURJTMIESA-N
InChI
1S/C6H15NO/c1-5(2)3-6(7)4-8/h5-6,8H,3-4,7H2,1-2H3/t6-/m0/s1
SMILES string
CC(C)C[C@H](N)CO
assay
96%
optical activity
[α]20/D +4°, c = 9 in ethanol
optical purity
ee: 99% (GLC)
reaction suitability
reaction type: solution phase peptide synthesis
refractive index
n20/D 1.4511 (lit.)
bp
198-200 °C/768 mmHg (lit.)
density
0.917 g/mL at 25 °C (lit.)
application(s)
peptide synthesis
Application
合成氨肽酶 N 和磷脂酶 A2 抑制剂的原料。
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
10 - Combustible liquids
wgk
WGK 3
flash_point_f
195.8 °F - closed cup
flash_point_c
91 °C - closed cup
ppe
Eyeshields, Gloves, type ABEK (EN14387) respirator filter
法规信息
新产品
此项目有
C Bennion et al.
Journal of medicinal chemistry, 35(16), 2939-2951 (1992-08-07)
A series of substrate analogue inhibitors of pancreatic phospholipase A2 has been designed and synthesized. The compounds were tested in a novel dual-screening system based on parallel assays with monomeric and micellar substrates. Intermolecular nuclear Overhauser effects between vinylic protons
David Schachter et al.
American journal of physiology. Heart and circulatory physiology, 282(3), H1135-H1148 (2002-02-09)
Rat aortic endothelium is differentiated regionally for three signal pathways capable of regulating the cGMP content of the underlying smooth muscle. Formation of nitric oxide (NO) from L-arginine and of glutamate from L-leucine increase cGMP; however, formation of prostaglandin H2
Klaus Ringsborg Westphal et al.
Toxins, 11(5) (2019-05-19)
Fungal non-ribosomal peptide synthetase (NRPS) clusters are spread across the chromosomes, where several modifying enzyme-encoding genes typically flank one NRPS. However, a recent study showed that the octapeptide fusaoctaxin A is tandemly synthesized by two NRPSs in Fusarium graminearum. Here
P T Pham et al.
Journal of cellular biochemistry, 79(3), 427-441 (2000-09-06)
Enhanced phosphorylation of the ribosomal protein s6 kinase, p70(s6k), and the translational repressor, 4E-BP1, are associated with either insulin-induced or amino acid-induced protein synthesis. Hyperphosphorylation of p70(s6k) and 4E-BP1 in response to insulin or amino acids is mediated through the
Chiral derivatives of xanthones and benzophenones: Synthesis, enantioseparation, molecular docking, and tumor cell growth inhibition studies.
Ye' Zaw Phyo et al.
Chirality, 33(4), 153-166 (2021-01-16)
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