188549
2-巯基吡啶-N-氧化物
99%
别名:
2-硫代-1-氧化吡啶, 吡啶硫酮
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关于此项目
经验公式（希尔记法）:
C5H5NOS
化学文摘社编号:
分子量:
127.16
UNSPSC Code:
12352100
NACRES:
NA.22
PubChem Substance ID:
EC Number:
214-329-4
Beilstein/REAXYS Number:
109936
MDL number:
产品名称
2-巯基吡啶-N-氧化物, 99%
InChI key
FGVVTMRZYROCTH-UHFFFAOYSA-N
InChI
1S/C5H5NOS/c7-6-4-2-1-3-5(6)8/h1-4,8H
SMILES string
[O-][n+]1ccccc1S
assay
99%
mp
69-72 °C (lit.)
Quality Level
Application
2-巯基吡啶 N -氧化物被用于研究巯基吡啶- N -氧化物杀菌剂的光降解机理 。它被用于哺乳动物细胞内锌离子的比率荧光成像 。
O-酰基硫代异羟化物的前体。与金属连接形成具有生物活性的复合物。
General description
2-巯基吡啶 N 氧化物与氯化钯反应生成配合物 。它抑制从 克氏锥虫中提纯的 NADH 富马酸还原酶 。它是 O -酰基硫代异羟酸盐的前体 。它与金属连接形成具有生物活性的复合物 。
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
J. Biopharm. Sci., 1, 331-331 (1990)
Matias Butler et al.
Journal of mass spectrometry : JMS, 52(11), 728-738 (2017-07-26)
2-Mercaptopyridine N-oxide (pyrithione, PTOH) along with several transition metal ions forms coordination compounds displaying notable biological activities. Gas-phase complexes formed between pyrithione and manganese (II), cobalt (II), nickel (II), copper (II), and zinc (II) were investigated by infusion in the
J F Turrens et al.
FEMS microbiology letters, 175(2), 217-221 (1999-07-01)
The enzyme NADH-fumarate reductase is not found in mammalian cells but it is present in several parasitic protozoa including Trypanosoma cruzi, the parasite that causes Chagas' disease. This study shows that the drug 2-mercaptopyridine-N-oxide (MPNO) inhibits NADH-fumarate reductase purified from
Vesna Lavtizar et al.
Ecotoxicology and environmental safety, 147, 132-138 (2017-08-26)
Copper pyrithione (CuPT) is a biocide, used worldwide to prevent biofouling on submerged surfaces. In aquatic environments it rapidly degrades, however, one of the degradation products (HPT) is known to react with cupric ion back to its parent compound. Not
Christopher J Chang et al.
Proceedings of the National Academy of Sciences of the United States of America, 101(5), 1129-1134 (2004-01-22)
Zinc is an essential metal ion for human growth and development, the disruption of cellular Zn(2+) homeostasis being implicated in several major disorders including Alzheimer's disease, diabetes, and cancer. The molecular mechanisms of Zn(2+) physiology and pathology are insufficiently understood
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