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Merck
CN

191906

羟丙基纤维素

average Mw ~1,000,000, powder, 20 mesh particle size (99% through)

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化学文摘社编号:
9004-64-2
UNSPSC Code:
12162002
NACRES:
NA.23
MDL number:
MFCD00132688

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SMILES string

N(C)(C)c1cc(c(cc1)C(N)CC)C

InChI

1S/C12H20N2/c1-5-12(13)11-7-6-10(14(3)4)8-9(11)2/h6-8,12H,5,13H2,1-4H3

InChI key

RRHXDYJWVYFMKV-UHFFFAOYSA-N

description

biological oxygen demand (BOD) 14,000 ppm

form

powder

autoignition temp.

752 °F

mol wt

average Mw ~1,000,000

impurities

<5 wt. %

particle size

20 mesh (99% through)

pH

5.0-8.5

interfacial tension mineral oil

12.5 dyn/cm, 0.1 wt. % in H2O (vs. mineral oil)

viscosity

1,275-3,500 cP, 1 wt. % in H2O(25 °C, Brookfield, spindle #3) (30 rpm)(lit.)

solubility

H2O: insoluble (above 45 °C), polar organic solvents: soluble

density

0.5 g/mL at 25 °C (lit.)

Quality Level

100

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相关类别

Application

  • 热响应性水性泡沫：研究人员已经研究了羟丙基纤维素作为绿色聚合物的性质，它可以随温度变化改变溶解性，适用于响应性泡沫应用 （Braunschweig, 2019）。
  • 水溶液中的相互作用机制：一项有关溶液中羟丙基纤维素和水相互作用的研究，重点关注了聚合物链长在确定溶液物理性质中的重要性 （Martin-Pastor and Stoyanov, 2020）。
  • 腐蚀抑制：研究显示了羟丙基纤维素作为酸性环境中铝腐蚀抑制剂的有效性，重点介绍了其在材料科学和工程应用中的潜力 （Jarkas et al., 2019）。
  • 口腔崩解膜：该应用涉及羟丙基纤维素膜的配方设计，目的在于改善药物的递送和溶出曲线，它在药物递送和药物科学中有重要意义 （Takeuchi et al., 2018）。

存储类别

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
MKCZ2521
MKCR8693
MKCN0594
MKCD5599
MKBC6263V

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Catherine Boissier et al.
Journal of pharmaceutical sciences, 101(7), 2512-2522 (2012-04-28)
Nuclear magnetic resonance (NMR) cryoporometry and scanning electron microscopy (SEM) image analysis have been used to investigate the size and shape distribution of pores in pharmaceutical coatings. The coatings were made from a mixture of hydroxypropylcellulose (HPC) and ethylcellulose (EC).
Kassibla E Dempah et al.
AAPS PharmSciTech, 14(1), 19-28 (2012-11-28)
Solid-state NMR spectroscopy (SSNMR), coupled with powder X-ray diffraction (PXRD), was used to identify the physical forms of gabapentin in samples prepared by recrystallization, spray drying, dehydration, and milling. Four different crystalline forms of gabapentin were observed: form I, a
Homendra Naorem et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 101, 67-73 (2012-10-27)
The formation constant of triiodide ions from iodine-iodide equilibrium in aqueous-organic solvent or polymer mixed media have been determined spectrophotometrically at three different temperatures 20, 30 and 40°C. The organic solvents chosen for the study are ethylene glycol, 2-methoxy ethanol
Noorullah Naqvi Mohammed et al.
AAPS PharmSciTech, 13(4), 1158-1169 (2012-09-11)
The objective of this research work was to evaluate Klucel™ hydroxypropylcellulose (HPC) EF and ELF polymers, for solubility enhancement as well as to address some of the disadvantages associated with solid dispersions. Ketoprofen (KPR), a Biopharmaceutics Classification System class II
Alexandre Monteiro et al.
Drug development and industrial pharmacy, 39(2), 266-283 (2012-04-17)
Nanoparticles of BCS Class II drugs are produced in wet stirred media mills operating in batch or recirculation mode with the goal of resolving the poor water-solubility issue. Scant information is available regarding the continuous production of drug nanoparticles via
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