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Merck
CN

191906

羟丙基纤维素

average Mw ~1,000,000, powder, 20 mesh particle size (99% through)

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化学文摘社编号:
9004-64-2
UNSPSC Code:
12162002
NACRES:
NA.23
MDL number:
MFCD00132688

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SMILES string

N(C)(C)c1cc(c(cc1)C(N)CC)C

InChI

1S/C12H20N2/c1-5-12(13)11-7-6-10(14(3)4)8-9(11)2/h6-8,12H,5,13H2,1-4H3

InChI key

RRHXDYJWVYFMKV-UHFFFAOYSA-N

description

biological oxygen demand (BOD) 14,000 ppm

form

powder

autoignition temp.

752 °F

mol wt

average Mw ~1,000,000

impurities

<5 wt. %

particle size

20 mesh (99% through)

pH

5.0-8.5

interfacial tension mineral oil

12.5 dyn/cm, 0.1 wt. % in H2O (vs. mineral oil)

viscosity

1,275-3,500 cP, 1 wt. % in H2O(25 °C, Brookfield, spindle #3) (30 rpm)(lit.)

solubility

H2O: insoluble (above 45 °C), polar organic solvents: soluble

density

0.5 g/mL at 25 °C (lit.)

Quality Level

100

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相关类别

Application

  • 热响应性水性泡沫：研究人员已经研究了羟丙基纤维素作为绿色聚合物的性质，它可以随温度变化改变溶解性，适用于响应性泡沫应用 （Braunschweig, 2019）。
  • 水溶液中的相互作用机制：一项有关溶液中羟丙基纤维素和水相互作用的研究，重点关注了聚合物链长在确定溶液物理性质中的重要性 （Martin-Pastor and Stoyanov, 2020）。
  • 腐蚀抑制：研究显示了羟丙基纤维素作为酸性环境中铝腐蚀抑制剂的有效性，重点介绍了其在材料科学和工程应用中的潜力 （Jarkas et al., 2019）。
  • 口腔崩解膜：该应用涉及羟丙基纤维素膜的配方设计，目的在于改善药物的递送和溶出曲线，它在药物递送和药物科学中有重要意义 （Takeuchi et al., 2018）。

存储类别

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
MKCZ2521
MKCR8693
MKCN0594
MKCD5599
MKBC6263V

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Alexandre Monteiro et al.
Drug development and industrial pharmacy, 39(2), 266-283 (2012-04-17)
Nanoparticles of BCS Class II drugs are produced in wet stirred media mills operating in batch or recirculation mode with the goal of resolving the poor water-solubility issue. Scant information is available regarding the continuous production of drug nanoparticles via
Hyemin Choi et al.
Journal of pharmaceutical sciences, 101(8), 2941-2951 (2012-05-26)
Living organisms secrete minerals composed of peptides and proteins, resulting in "mesocrystals" of three-dimensional-assembled composite structures. Recently, this biomimetic polymer-directed crystallization technique has been widely applied to inorganic materials, although it has seldom been used with drugs. In this study
Ranjit M Dhenge et al.
International journal of pharmaceutics, 438(1-2), 20-32 (2012-09-11)
The present work focuses on the study of the progression of granules in different compartments along the length of screws in a twin screw granulator (TSG). The effects of varying powder feed rate; liquid to solid ratio and viscosity of
Maya Fujiwara et al.
Chemical & pharmaceutical bulletin, 60(11), 1380-1386 (2012-11-06)
We evaluated models for predicting spray mist diameter suitable for scaling-up the fluidized bed granulation process. By precise selection of experimental conditions, we were able to identify a suitable prediction model that considers changes in binder solution, nozzle dimension, and
Weibin Deng et al.
Drug development and industrial pharmacy, 39(2), 290-298 (2012-04-25)
The objective of this study was to improve the dissolution rate and to enhance the stability of a poorly water-soluble and low glass-trasition temperature (T(g)) model drug, fenofibrate, in low molecular weight grades of hydroxypropylcellulose matrices produced by hot-melt extrusion
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