质量水平
方案
≥98.0% (T)
mp
114-116 °C
溶解性
alcohol: soluble(lit.)
diethyl ether: slightly soluble(lit.)
water: soluble(lit.)
官能团
amide
SMILES字符串
CCCC(N)=O
InChI
1S/C4H9NO/c1-2-3-4(5)6/h2-3H2,1H3,(H2,5,6)
InChI key
DNSISZSEWVHGLH-UHFFFAOYSA-N
基因信息
rat ... Ggt1(116568)
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应用
Butyramide was used in the synthesis of hydroxamic acids, electrorheological fluids and β-amodoorganotin compounds. It was used as substrate of (+)-γ-lactamase to develop a microreactor to study enzyme stability, activity, kinetics and substrate specificity.
储存分类代码
13 - Non Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
Jiang Hong et al.
Biophysical journal, 109(1), 144-153 (2015-07-15)
Biopolymer homeostasis underlies the health of organisms, and protective osmolytes have emerged as one strategy used by Nature to preserve biopolymer homeostasis. However, a great deal remains unknown about the mechanism of action of osmolytes. Trehalose, as a prominent example
Maja D Vitorović-Todorović et al.
Bioorganic & medicinal chemistry, 18(3), 1181-1193 (2010-01-12)
Synthesis and anticholinesterase activity of 4-aryl-4-oxo-N-phenyl-2-aminylbutyramides, novel class of reversible, moderately potent cholinesterase inhibitors, are reported. Simple substituent variation on aroyl moiety changes anti-AChE activity for two orders of magnitude; also substitution and type of hetero(ali)cycle in position 2 of
Giuseppina Mattace Raso et al.
PloS one, 8(7), e68626-e68626 (2013-07-19)
Nonalcoholic fatty liver disease (NAFLD) is the most common form of chronic liver disease. Insulin resistance (IR) appears to be critical in its pathogenesis. We evaluated the effects of sodium butyrate (butyrate) and its synthetic derivative N-(1-carbamoyl-2-phenyl-ethyl) butyramide (FBA) in
Jiahua Jiang et al.
PloS one, 7(3), e34283-e34283 (2012-04-06)
We have recently synthesized novel N-alkylated amino acid-derived hydroxamate, 2-[Benzyl-(2-nitro-benzenesulfonyl)-amino]-N-hydroxy-3-methyl-N-propyl-butyramide (NAHA). Here, we evaluate the anticancer activity of NAHA against highly invasive human breast cancer cells MDA-MB-231 in vitro and in vivo. Cell growth was evaluated by MTT and soft
Hongjian Zhang et al.
Drug metabolism and disposition: the biological fate of chemicals, 35(5), 795-805 (2007-02-17)
2-{Butyryl-[2'-(4,5-dimethyl-isoxazol-3-ylsulfamoyl)-biphenyl-4-ylmethyl]-amino}-N-isopropyl-3-methyl-butyramide (BMS-1) is a potent dual acting angiotensin-1 and endothelin-A receptor antagonist. The compound was subject to rapid metabolic clearance in monkey and human liver microsomes and exhibited low systemic exposure and marked interanimal variability in cynomolgus monkeys after p.o.
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