194557
甲氧基乙酸
98%
别名:
NSC 7300
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线性分子式:
CH3OCH2COOH
化学文摘社编号:
分子量:
90.08
UNSPSC Code:
12352100
NACRES:
NA.22
PubChem Substance ID:
EC Number:
210-894-6
Beilstein/REAXYS Number:
635800
MDL number:
产品名称
甲氧基乙酸, 98%
InChI key
RMIODHQZRUFFFF-UHFFFAOYSA-N
InChI
1S/C3H6O3/c1-6-2-3(4)5/h2H2,1H3,(H,4,5)
SMILES string
COCC(O)=O
assay
98%
form
liquid
refractive index
n20/D 1.417 (lit.)
bp
202-204 °C (lit.)
mp
7-9 °C (lit.)
density
1.174 g/mL at 25 °C (lit.)
functional group
carboxylic acid
ether
Quality Level
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Application
甲氧基乙酸被用于斑马鱼胚胎毒性试验，以评估卵内胚胎发育过程中完整脊椎动物胚胎暴露后的化学毒性。
General description
甲氧基乙酸是邻苯二甲酸酯的主要代谢物，广泛用于工业中作为胶凝剂、粘度剂和稳定剂。
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Eye Dam. 1 - Repr. 1B - Skin Corr. 1B - STOT SE 3
target_organs
Respiratory system
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 2
flash_point_f
237.2 °F - closed cup
flash_point_c
114 °C - closed cup
ppe
Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter
Gargi Bagchi et al.
Reproductive biology and endocrinology : RB&E, 9, 42-42 (2011-04-02)
Optimal androgen signaling is critical for testicular development and spermatogenesis. Methoxyacetic acid (MAA), the primary active metabolite of the industrial chemical ethylene glycol monomethyl ether, disrupts spermatogenesis and causes testicular atrophy. Transcriptional trans-activation studies have indicated that MAA can enhance
Bo Yang et al.
Urology, 81(3), 696-696 (2013-01-08)
To investigate the expression pattern of Ras-related protein 1 (Rap1) during testicular development and to clarify whether its expression is developmentally regulated and whether this expression is involved in the process of germ cell apoptosis. The expression pattern of Rap1
Derek V Henley et al.
Endocrinology, 147(6 Suppl), S25-S32 (2006-05-13)
The term endocrine-disrupting chemicals is used to define a structurally diverse class of synthetic and natural compounds that possess the ability to alter various components of the endocrine system and potentially induce adverse health effects in exposed individuals and populations.
Gargi Bagchi et al.
Reproductive biology and endocrinology : RB&E, 8, 65-65 (2010-06-23)
Methoxyacetic acid (MAA) is the active metabolite of the widely used industrial chemical ethylene glycol monomethyl ether, which is associated with various developmental and reproductive toxicities, including neural toxicity, blood and immune disorders, limb degeneration and testicular toxicity. Testicular toxicity
Derek V Henley et al.
Environmental health perspectives, 117(11), 1702-1706 (2010-01-06)
Ethylene glycol monomethyl ether (EGME) exposure is associated with impaired reproductive function. The primary metabolite of EGME is methoxyacetic acid (MAA), a short-chain fatty acid that inhibits histone deacetylase activity and alters gene expression. Because estrogen signaling is necessary for
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