质量水平
方案
98%
表单
liquid
折射率
n20/D 1.417 (lit.)
沸点
202-204 °C (lit.)
mp
7-9 °C (lit.)
密度
1.174 g/mL at 25 °C (lit.)
官能团
carboxylic acid
ether
SMILES字符串
COCC(O)=O
InChI
1S/C3H6O3/c1-6-2-3(4)5/h2H2,1H3,(H,4,5)
InChI key
RMIODHQZRUFFFF-UHFFFAOYSA-N
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一般描述
甲氧基乙酸是邻苯二甲酸酯的主要代谢物，广泛用于工业中作为胶凝剂、粘度剂和稳定剂。
应用
甲氧基乙酸被用于斑马鱼胚胎毒性试验，以评估卵内胚胎发育过程中完整脊椎动物胚胎暴露后的化学毒性。
警示用语：
Danger
危险分类
Acute Tox. 4 Oral - Eye Dam. 1 - Repr. 1B - Skin Corr. 1B - STOT SE 3
靶器官
Respiratory system
储存分类代码
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 2
闪点(°F)
237.2 °F - closed cup
闪点(°C)
114 °C - closed cup
个人防护装备
Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter
Derek V Henley et al.
Environmental health perspectives, 117(11), 1702-1706 (2010-01-06)
Ethylene glycol monomethyl ether (EGME) exposure is associated with impaired reproductive function. The primary metabolite of EGME is methoxyacetic acid (MAA), a short-chain fatty acid that inhibits histone deacetylase activity and alters gene expression. Because estrogen signaling is necessary for
Derek V Henley et al.
Endocrinology, 147(6 Suppl), S25-S32 (2006-05-13)
The term endocrine-disrupting chemicals is used to define a structurally diverse class of synthetic and natural compounds that possess the ability to alter various components of the endocrine system and potentially induce adverse health effects in exposed individuals and populations.
Gargi Bagchi et al.
Reproductive biology and endocrinology : RB&E, 8, 65-65 (2010-06-23)
Methoxyacetic acid (MAA) is the active metabolite of the widely used industrial chemical ethylene glycol monomethyl ether, which is associated with various developmental and reproductive toxicities, including neural toxicity, blood and immune disorders, limb degeneration and testicular toxicity. Testicular toxicity
Gargi Bagchi et al.
Reproductive biology and endocrinology : RB&E, 9, 42-42 (2011-04-02)
Optimal androgen signaling is critical for testicular development and spermatogenesis. Methoxyacetic acid (MAA), the primary active metabolite of the industrial chemical ethylene glycol monomethyl ether, disrupts spermatogenesis and causes testicular atrophy. Transcriptional trans-activation studies have indicated that MAA can enhance
Bo Yang et al.
Urology, 81(3), 696-696 (2013-01-08)
To investigate the expression pattern of Ras-related protein 1 (Rap1) during testicular development and to clarify whether its expression is developmentally regulated and whether this expression is involved in the process of germ cell apoptosis. The expression pattern of Rap1
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