195421
10,11-二氢酰胺咪嗪
99%
别名:
10,11-二氢-5H-二苯并[b,f]氮杂卓-5-甲酰胺
方案
99%
表单
solid
mp
205-210 °C (lit.)
溶解性
dichloromethane: soluble 2.5%, clear, colorless
官能团
amine
SMILES字符串
NC(=O)N1c2ccccc2CCc3ccccc13
InChI
1S/C15H14N2O/c16-15(18)17-13-7-3-1-5-11(13)9-10-12-6-2-4-8-14(12)17/h1-8H,9-10H2,(H2,16,18)
InChI key
PHNLCHMJDSSPDQ-UHFFFAOYSA-N
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一般描述
10,11-Dihydrocarbamazepine is an impurity present in dibenzazepine drug used in the treatment of epilepsy. Single-crystal structure of new dimer-based polymorph of 10,11-dihydrocarbamazepine has been investigated.
应用
10,11-Dihydrocarbamazepine was used as internal standard during simultaneous determination of carbamazepine and its active metabolite in plasma by liquid chromatography. It was used in chemiluminescence method for determination of carbamazepine.
警示用语：
Danger
危险分类
Acute Tox. 4 Oral - Repr. 1A - Skin Sens. 1A - STOT SE 3
靶器官
Central nervous system
储存分类代码
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Sang Hak Lee et al.
Analytical sciences : the international journal of the Japan Society for Analytical Chemistry, 19(6), 903-906 (2003-07-02)
A new chemiluminescence method for the determination of carbamazepine (CBZ) has been developed. The method is based on the chemiluminescence produced in the reaction of tris(2,2'-bipyridine)ruthenium(III) and CBZ in an acidic medium. The chemiluminescence intensity was enhanced by organic solvents
M Eichelbaum et al.
Journal of chromatography, 103(1), 135-140 (1975-01-14)
A liquid-chromatographic method for the simultaneous determination of carbamazepine and its active metabolite (carbamazepine 10,11-epoxide) in plasma has been developed. The two compounds were identified in plasma by mass spectrometry. The lower limit of sensitivity is about 4 and 40
A predicted dimer-based polymorph of 10, 11-dihydrocarbamazepine (Form IV).
Arlin J-B, et al.
CrystEngComm, 12(1), 64-66 (2010)
T D Cyr et al.
Journal - Association of Official Analytical Chemists, 70(5), 836-840 (1987-09-01)
Liquid chromatographic (LC) methods have been developed for the determination of carbamazepine, the impurity 10,11-dihydrocarbamazepine, and related compounds in carbamazepine drug substance and tablets. The LC methods specify a 5 micron diol column and a mobile phase of acetonitrile-methanol-0.05% aqueous
M G Bixel et al.
European journal of biochemistry, 267(1), 110-120 (1999-12-22)
Several wasp venoms contain philanthotoxins (PhTXs), natural polyamine amides, which act as noncompetitive inhibitors (NCIs) on the nicotinic acetylcholine receptor (nAChR). Effects of varying the structure of PhTXs and poly(methylene tetramine)s on the binding affinity have been investigated. Using the
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