197343
甲基锂 溶液
1.6 M in diethyl ether
别名:
Lithium methanide, MeLi
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关于此项目
经验公式（希尔记法）:
CH3Li
化学文摘社编号:
分子量:
21.98
UNSPSC Code:
12352103
NACRES:
NA.22
PubChem Substance ID:
MDL number:
Beilstein/REAXYS Number:
3587162
Concentration:
1.6 M in diethyl ether
Form:
liquid
InChI
1S/CH3.Li/h1H3;
SMILES string
[Li]C
InChI key
DVSDBMFJEQPWNO-UHFFFAOYSA-N
vapor density
3 (vs air)
form
liquid
composition
halide, ~0.05 M
concentration
1.6 M in diethyl ether
density
0.732 g/mL at 25 °C
storage temp.
2-8°C
Quality Level
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General description
甲基锂是一种有机锂试剂，主要用于去质子化和作为甲基阴离子的来源。它是一种强碱和强亲核体。
Application
在手性铜催化剂存在下，甲基锂水溶液（1.6 M 乙醚中）已用于烯丙基亲电试剂的不对称烯丙基烷基化反应。该方案导致具有高度对映选择性的三级和四级立体中心的 C-C 键形成。它也可用于在（ - ） - 鹰爪豆碱作为手性配体存在下与6,7-二甲氧基-3,4-二氢异喹啉反应而用于合成（ - ） - 猪毛菜碱。
Legal Information
Sure/Seal is a trademark of Sigma-Aldrich Co. LLC
signalword
Danger
supp_hazards
存储类别
4.2 - Pyrophoric and self-heating hazardous materials
wgk
WGK 1
flash_point_f
1.4 °F - closed cup
flash_point_c
-17 °C - closed cup
Hazard Classifications
Acute Tox. 4 Oral - Flam. Liq. 2 - Pyr. Liq. 1 - Skin Corr. 1B - STOT SE 3 - Water-react. 1
法规信息
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