199915
1-甲基-4-苯基-1,2,3,6-四氢吡啶
97%
别名:
MPTP
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经验公式（希尔记法）:
C12H15N
化学文摘社编号:
分子量:
173.25
UNSPSC Code:
12352200
PubChem Substance ID:
MDL number:
Assay:
97%
Form:
solid
InChI
1S/C12H15N/c1-13-9-7-12(8-10-13)11-5-3-2-4-6-11/h2-7H,8-10H2,1H3
SMILES string
CN1CCC(=CC1)c2ccccc2
InChI key
PLRACCBDVIHHLZ-UHFFFAOYSA-N
assay
97%
form
solid
drug control
kontrollierte Droge in Deutschland, regulated under CDSA - not available from Sigma-Aldrich Canada
bp
128-132 °C/12 mmHg (lit.)
functional group
phenyl
Biochem/physiol Actions
Dopaminergic neurotoxin.
Legal Information
German
Dieses Produkt fällt unter das Betäubungsmittelgesetz (BtMG). Für eine Bestellung dieses Produktes ist eine Erlaubnis nach § 3 BtMG zwingend erforderlich, es sei denn, es greift eine Ausnahme von der Erlaubnispflicht nach § 4 oder § 26 BtMG.
English
This product is subject to the German Narcotics Act. A permit under Section 3 of the German Narcotics Act is mandatory for ordering this product unless an exemption from the permit requirement under Section 4 or Section 26 of the German Narcotics Act applies.
Dieses Produkt fällt unter das Betäubungsmittelgesetz (BtMG). Für eine Bestellung dieses Produktes ist eine Erlaubnis nach § 3 BtMG zwingend erforderlich, es sei denn, es greift eine Ausnahme von der Erlaubnispflicht nach § 4 oder § 26 BtMG.
English
This product is subject to the German Narcotics Act. A permit under Section 3 of the German Narcotics Act is mandatory for ordering this product unless an exemption from the permit requirement under Section 4 or Section 26 of the German Narcotics Act applies.
Disclaimer
Reportedly causes a severe and irreversible Parkinsonism condition in humans and monkeys. New Engl. J. Med. 1983, 309, 310. Science 1983, 219, 979. ibid. 1984, 224, 1083, 1451. ibid. 1984, 225, 529. J. Med. Chem. 1985, 28, 997.
signalword
Danger
hcodes
pcodes
Hazard Classifications
Acute Tox. 3 Oral - STOT SE 1
存储类别
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
wgk
WGK 3
flash_point_f
235.4 °F - closed cup
flash_point_c
113 °C - closed cup
法规信息
新产品
此项目有
Gejuan Zhang et al.
Life sciences, 232, 116600-116600 (2019-06-30)
Neuroinflammation is one of the significant neuropathological conditions in Parkinson's disease (PD) which is due to microglial and astrocytes activation leads to progressive dopaminergic neuronal loss. To date, Current PD drugs offers only symptomatic relief with adverse effects and lack
Hideaki Matsui et al.
Journal of neural transmission (Vienna, Austria : 1996), 125(1), 25-33 (2017-08-05)
Parkinson's disease is a neurodegenerative disorder that involves movement discloses, degeneration of dopaminergic neurons, and presence of cytoplasmic inclusion bodies. Various animal models have been developed and small fish including zebrafish and medaka fish have recently been employed as a
Anamitra Ghosh et al.
Science translational medicine, 8(368), 368ra174-368ra174 (2016-12-09)
Mitochondrial and autophagic dysfunction as well as neuroinflammation are involved in the pathophysiology of Parkinson's disease (PD). We hypothesized that targeting the mitochondrial pyruvate carrier (MPC), a key controller of cellular metabolism that influences mTOR (mammalian target of rapamycin) activation
Yuanyuan Liu et al.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 40(1-2), 18-26 (2016-11-15)
Development of effective therapeutic drugs for Parkinson's disease is in great need. During the progression of Parkinson's disease, Rho-associated protein kinase 2 (ROCK2) is activated to promote neurodegeneration. Hydrogen sulfide (H2S) has a neuroprotective effect during the neural injury of
Yu-Qing Yuan et al.
Brain, behavior, and immunity, 67, 77-90 (2017-08-05)
Hydrogen sulfide (H
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