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Merck
CN

202495

Sigma-Aldrich

聚乙二醇甲基醚

average MN 750, methoxy, hydroxyl

别名:

mPEG, 甲氧基聚乙二醇, 聚乙二醇单甲醚

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关于此项目

线性分子式:
CH3(OCH2CH2)nOH
化学文摘社编号:
9004-74-4
MDL编号:
MFCD00084416
UNSPSC代码:
12162002
PubChem化学物质编号:
24852093
NACRES:
NA.23

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产品名称

聚乙二醇甲基醚, average Mn 750

蒸汽密度

>1 (vs air)

质量水平

200

蒸汽压

0.05 mmHg ( 20 °C)

表单

paste
solid

分子量

average Mn 750

折射率

n20/D 1.459

粘度

10.5 cSt(210 °F)(lit.)

转变温度

Tm 30 °C

密度

1.094 g/mL at 25 °C

Ω端

hydroxyl

α端

methoxy

SMILES字符串

O(CCO)C

InChI

1S/C3H8O2/c1-5-3-2-4/h4H,2-3H2,1H3

InChI key

XNWFRZJHXBZDAG-UHFFFAOYSA-N

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应用

聚（乙二醇）甲基醚可用作：
  • 一种链转移剂，以通过金属开环寡聚反应合成两亲性嵌段共聚物。
  • 作为一种前体，用于制备视甲酸-聚乙二醇纳米组装体，以作为一种高效的药物给药系统
  • 制备与聚乳酸结合的双嵌段共聚物，并将其应用于组织工程和给药领域

储存分类代码

10 - Combustible liquids

WGK

WGK 1

闪点(°F)

359.6 °F - closed cup

闪点(°C)

182 °C - closed cup

个人防护装备

Eyeshields, Gloves

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
MKCX8777
MKCW3308
0000214565
0000214565
MKCV2901

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Lei Liu et al.
International journal of pharmaceutics, 443(1-2), 175-182 (2013-01-05)
This work aims to develop curcumin (Cur) loaded biodegradable self-assembled polymeric micelles (Cur-M) to overcome poor water solubility of Cur and to meet the requirement of intravenous administration. Cur-M were prepared by solid dispersion method, which was simple and easy
Yi Wei et al.
Langmuir : the ACS journal of surfaces and colloids, 28(39), 13984-13992 (2012-09-04)
The microcosmic mechanisms of protein (recombinant human growth hormone, rhGH) incomplete release and stability from amphiphilic poly(monomethoxypolyethylene glycol-co-D,L-lactide) (mPEG-PLA, PELA) microspheres were investigated. PELA with different hydrophilicities (PELA-1, PELA-2, and PELA-3) based on various ratios of mPEG to PLA were
Prakash G Avaji et al.
Bioorganic & medicinal chemistry letters, 23(6), 1763-1767 (2013-02-16)
Saturated fatty acids (FA) were grafted using tyrosine as a spacer group to the cyclotriphosphazene ring along with equimolar hydrophilic methoxy poly(ethylene glycol) (MPEG) in cis-nongeminal way. Seven new cyclotriphosphazene amphiphiles were prepared from combinations of hydrophilic MPEGs with different
Yiyi Yu et al.
Journal of pharmaceutical sciences, 102(3), 1054-1062 (2013-01-03)
To promote the application of methoxy poly(ethylene glycol)-cholesterol (mPEG-Chol), mPEG-Chol was used to prepare core-shell micelles encapsulating poorly water-soluble docetaxel (DTX-PM) by modified cosolvent evaporation method. Approaches to enhance DTX entrapment efficiency (EE) and minimize particle size were investigated in
Seung-Young Lee et al.
Biomaterials, 34(2), 552-561 (2012-10-20)
Although targeted delivery mediated by ligand modified or tumor microenvironment sensitive nanocarriers has been extensively pursued for cancer chemotherapy, the efficiency is still limited by premature drug release after systemic administration. Herein we report a highly blood-stable, tumor-adaptable drug carrier
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