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Merck
CN

202495

聚乙二醇甲基醚

average MN 750, methoxy, hydroxyl

别名:

mPEG, 甲氧基聚乙二醇, 聚乙二醇单甲醚

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关于此项目

线性分子式:
CH3(OCH2CH2)nOH
化学文摘社编号:
9004-74-4
UNSPSC Code:
12162002
PubChem Substance ID:
24852093
NACRES:
NA.23
MDL number:
MFCD00084416

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产品名称

聚乙二醇甲基醚, average Mn 750

SMILES string

O(CCO)C

InChI

1S/C3H8O2/c1-5-3-2-4/h4H,2-3H2,1H3

InChI key

XNWFRZJHXBZDAG-UHFFFAOYSA-N

vapor density

>1 (vs air)

vapor pressure

0.05 mmHg ( 20 °C)

form

paste
solid

mol wt

average Mn 750

refractive index

n20/D 1.459

viscosity

10.5 cSt(210 °F)(lit.)

transition temp

Tm 30 °C

density

1.094 g/mL at 25 °C

Ω-end

hydroxyl

α-end

methoxy

Quality Level

200

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相关类别

Application

聚（乙二醇）甲基醚可用作：
  • 一种链转移剂，以通过金属开环寡聚反应合成两亲性嵌段共聚物。
  • 作为一种前体，用于制备视甲酸-聚乙二醇纳米组装体，以作为一种高效的药物给药系统
  • 制备与聚乳酸结合的双嵌段共聚物，并将其应用于组织工程和给药领域

存储类别

10 - Combustible liquids

wgk

WGK 1

flash_point_f

359.6 °F - closed cup

flash_point_c

182 °C - closed cup

ppe

Eyeshields, Gloves

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
MKCX8777
MKCW3308
0000214565
0000214565
MKCV2901

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Yiyi Yu et al.
Journal of pharmaceutical sciences, 102(3), 1054-1062 (2013-01-03)
To promote the application of methoxy poly(ethylene glycol)-cholesterol (mPEG-Chol), mPEG-Chol was used to prepare core-shell micelles encapsulating poorly water-soluble docetaxel (DTX-PM) by modified cosolvent evaporation method. Approaches to enhance DTX entrapment efficiency (EE) and minimize particle size were investigated in
Pengxiang Zhao et al.
Chemical communications (Cambridge, England), 49(31), 3218-3220 (2013-03-14)
"Click" chemistry now offers access to a great variety of triazoles, and the first example of a strategy to stabilize gold nanoparticles (AuNPs) with a new 1,2,3-triazole-mPEG ligand is developed here together with preliminary examples of possible applications.
Lina Du et al.
Anti-cancer drugs, 24(2), 172-180 (2012-09-20)
A functionalized poly(amidoamine) (PAMAM) nanocarrier was designed and prepared to deliver anticancer drugs. The nanocarrier is a copolymer with a core-shell structure with 3.0 G PAMAM as the core and sequentially conjugated poly(2-(N,N-diethylamino)ethyl methacrylate) (pDEA) and methoxy-poly(ethylene glycol) 2000 (mPEG)
Mulu Z Tesfay et al.
Journal of virology, 87(7), 3752-3759 (2013-01-18)
We are developing oncolytic vesicular stomatitis viruses (VSVs) for systemic treatment of multiple myeloma, an incurable malignancy of antibody-secreting plasma cells that are specifically localized in the bone marrow. One of the presumed advantages for using VSV as an oncolytic
Seung-Young Lee et al.
Biomaterials, 34(2), 552-561 (2012-10-20)
Although targeted delivery mediated by ligand modified or tumor microenvironment sensitive nanocarriers has been extensively pursued for cancer chemotherapy, the efficiency is still limited by premature drug release after systemic administration. Herein we report a highly blood-stable, tumor-adaptable drug carrier
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